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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Transmembrane Transporters >CFTR inhibitors >Ataluren

Ataluren

Ataluren Structure
  • ₹18830
  • Product name: Ataluren
  • CAS: 775304-57-9
  • MF: C15H9FN2O3
  • MW: 284.24
  • EINECS:
  • MDL Number:MFCD09864996
  • Synonyms:Ptc-124;PTC-124,ataluren;Ataluren (PTC124);Ataluren PTC 124 Ataluren;Ataluren, >=98%;PTC124, 775304-57-9;3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid;Ataluren [usan]
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number5.30918
  • Product descriptionPTC-124 - CAS 775304-57-9 - Calbiochem
  • Packaging25MG
  • Price₹18830
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 5.30918 PTC-124 - CAS 775304-57-9 - Calbiochem 25MG ₹18830 2022-06-14 Buy

Properties

Melting point :241 - 242°C
Boiling point :503.7±60.0 °C(Predicted)
Density :1.379
storage temp. :Refrigerator
solubility :DMSO (Slightly)
form :White to off-white solid.
pka :3.58±0.10(Predicted)
color :White to Off-White
InChI :InChI=1S/C15H9FN2O3/c16-12-7-2-1-6-11(12)14-17-13(18-21-14)9-4-3-5-10(8-9)15(19)20/h1-8H,(H,19,20)
InChIKey :OOUGLTULBSNHNF-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=CC(C2N=C(C3=CC=CC=C3F)ON=2)=C1
CAS DataBase Reference :775304-57-9

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P314 Get medical advice/attention if you feel unwell.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.

Description

Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.

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