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ChemicalBook > Product Catalogue >Natural Products >Flavonoids >BRAZILIN

BRAZILIN

BRAZILIN Structure
  • ₹9729 - ₹44155.8
  • Product name: BRAZILIN
  • CAS: 474-07-7
  • MF: C16H14O5
  • MW: 286.28
  • EINECS:207-477-6
  • MDL Number:MFCD00210817
  • Synonyms:NSC 56652;7,11b-dihydroindeno[2,1-c]chromene-3,6a,9,10(6H)-tetrol;2-d)pyran-3,6a,9,10(6h)-tetrol,7,11b-dihydro-benz(b)indeno( ;6a,9,10(6h)-tetrol,7,11b-dihydro-2-d]pyran-(6as-cis)-benz[b]indeno[ ;7,11b-dihydrobenz(b)indeno(1,2-d)pyran-3,6a,9,10(6h)-tetrol ;brasilin ;braziletto ;hypernicextract
5 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 5MG
  • 25MG
  • 100mg
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2132
  • Product descriptionBrazilin
  • Packaging5MG
  • Price₹10955.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2132
  • Product descriptionBrazilin
  • Packaging25MG
  • Price₹44155.8
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number B 1990
  • Product descriptionBrazilin 98%
  • Packaging5mg
  • Price₹9729
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number B 1990
  • Product descriptionBrazilin 98%
  • Packaging100mg
  • Price₹10809
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number B 1990
  • Product descriptionBrazilin 98%
  • Packaging25mg
  • Price₹39069
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML2132 Brazilin 5MG ₹10955.7 2022-06-14 Buy
Sigma-Aldrich(India) SML2132 Brazilin 25MG ₹44155.8 2022-06-14 Buy
ottokemi B 1990 Brazilin 98% 5mg ₹9729 2022-05-26 Buy
ottokemi B 1990 Brazilin 98% 100mg ₹10809 2022-05-26 Buy
ottokemi B 1990 Brazilin 98% 25mg ₹39069 2022-05-26 Buy

Properties

Melting point :156-157℃
Boiling point :348.65°C (rough estimate)
Density :1.1924 (rough estimate)
refractive index :1.6200 (estimate)
solubility :DMSO:43.5(Max Conc. mg/mL);151.95(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);104.79(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);104.79(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);34.93(Max Conc. mM) form :A crystalline solid
color :Yellow to brown
EPA Substance Registry System :Brazilin (474-07-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 μM) more potently than (-)-epigallocatechin gallate , cucurmin , and resveratrol (Item Nos. 10004235 | 70675). It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 and TNF-α (IC50s = 12.6 and 87.2 μM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 μg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.

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