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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Leucine derivatives >Boc-N-methyl-L-leucine

Boc-N-methyl-L-leucine

Boc-N-methyl-L-leucine Structure
  • ₹9270 - ₹20870.6
  • Product name: Boc-N-methyl-L-leucine
  • CAS: 53363-89-6
  • MF: C12H23NO4
  • MW: 245.32
  • EINECS:
  • MDL Number:MFCD00038522
  • Synonyms:N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE;N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE;BOC-BETA-TBU-ALANINE;BOC-BETA-TBU-ALA-OH
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5G
  • ManufacturerSigma-Aldrich(India)
  • Product number8.53083
  • Product descriptionBoc-N-Me-Leu-OH Novabiochem?
  • Packaging5G
  • Price₹9270
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number15446
  • Product descriptionBoc-N-Me-Leu-OH ≥99.0% (sum of enantiomers, TLC)
  • Packaging5G
  • Price₹20870.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 8.53083 Boc-N-Me-Leu-OH Novabiochem? 5G ₹9270 2022-06-14 Buy
Sigma-Aldrich(India) 15446 Boc-N-Me-Leu-OH ≥99.0% (sum of enantiomers, TLC) 5G ₹20870.6 2022-06-14 Buy

Properties

Melting point :55-60 °C
Boiling point :338.2±21.0 °C(Predicted)
Density :1.053±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
pka :4.04±0.21(Predicted)
form :Solid
color :White to off-white
optical activity :[α]20/D 36±2°, c = 1% in methylene chloride
BRN :2373250
InChI :InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
InChIKey :YXJFAOXATCRIKU-VIFPVBQESA-N
SMILES :C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference :53363-89-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.

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