CHARTREUSIN
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- ₹0
- Product name: CHARTREUSIN
- CAS: 6377-18-0
- MF: C32H32O14
- MW: 640.59
- EINECS:
- MDL Number:MFCD00467138
- Synonyms:CHARTREUSIN;antibioticx-465a ;nsc5159 ;u-7257 ;chartreusin from streptomyces*chartreusis;LAMBDAMYCIN;10-[[6-Deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione;LaMbdaMycin, NSC 5159, 747, 1293, X465A, G 261A
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Properties
Melting point :185℃
alpha :D25 +132.5° (c = 0.2 in pyridine); D25 -33° (c = 0.3 in glacial acetic acid)
Boiling point :592.39°C (rough estimate)
Density :1.3027 (rough estimate)
refractive index :1.6130 (estimate)
storage temp. :2-8°C
solubility :Chloroform (Slightly, Heated), Methanol (Slightly), Pyridine (Slightly)
form :Yellow solid.
pka :6?+-.0.20(Predicted)
color :Light Yellow to Yellow
Water Solubility :15mg/L(25 ºC)
Stability :Hygroscopic
alpha :D25 +132.5° (c = 0.2 in pyridine); D25 -33° (c = 0.3 in glacial acetic acid)
Boiling point :592.39°C (rough estimate)
Density :1.3027 (rough estimate)
refractive index :1.6130 (estimate)
storage temp. :2-8°C
solubility :Chloroform (Slightly, Heated), Methanol (Slightly), Pyridine (Slightly)
form :Yellow solid.
pka :6?+-.0.20(Predicted)
color :Light Yellow to Yellow
Water Solubility :15mg/L(25 ºC)
Stability :Hygroscopic
Safety Information
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Description
Chartreusin is a potent anti-proliferative agent originally derived from Streptomyces chartreusis. This compound has been shown to be a potent inhibitor of the catalytic activity of Topo II (topoisomerase II). Experiments have reported that Chartreusin binds to GC-rich tracts in DNA, inhibits RNA synthesis, and causes single-strand scission of DNA via formation of free radicals. Additionally, this agent has been shown to inhibit formation of several DNA-protein complexes.More related product prices
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