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CPNQ

CPNQ Structure
  • ₹17731.35
  • Product name: CPNQ
  • CAS: 115687-05-3
  • MF: C20H17ClN4O3
  • MW: 396.83
  • EINECS:
  • MDL Number:MFCD02039810
  • Synonyms:5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline;B2;Linazolamide intermediate B impurity 2;(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone;SIRT2 Inhibitor, B2;Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-;Sirtuin,Parkinson’s diseases,Huntington’s diseases,Inhibitor,B2,inhibit,B-2;SIRT2-IN-8
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3118
  • Product descriptionCPNQ ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹17731.35
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C3118 CPNQ ≥98% (HPLC), solid 5MG ₹17731.35 2022-06-14 Buy

Properties

Melting point :174-176°C
Boiling point :645.5±55.0 °C(Predicted)
Density :1.412±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :H2O: insoluble <2mg/mL
pka :2.30±0.29(Predicted)
form :solid
color :brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2) (IC50 = 35 μM). B2 promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. B2 prevents Huntington-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. SIRT2 is known to deacetylate histones.

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