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ChemicalBook > Product Catalogue >API >Antibiotics >Cephalosporins Drugs >Cefuroxime

Cefuroxime

Cefuroxime Structure
  • ₹27841.9
  • Product name: Cefuroxime
  • CAS: 55268-75-2
  • MF: C16H16N4O8S
  • MW: 424.39
  • EINECS:259-560-1
  • MDL Number:MFCD00864889
  • Synonyms:ethyl)-7-((2-furanyl(methyoxyimino)acetyl)amino)-8-oxo-,(6r-(6-alpha,7-beta(z ;1-ACETYLOXYETHYL 4-(CARBAMOYLOXYMETHYL)-8-[2-(2-FURYL)-2-METHOXYIMINO-ACETYL]AMINO-7-OXO-2-THIA-6-AZABICYCLO[4.2.0]OCT-4-ENE-5-CARBOXYLATE;(6r-(6alpha,7beta(z)))-3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)a cetyl)-amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(acetyloxy)ethyl ester;Cefuroxime Axetil EP 8.0 Impurity D;cefaloxime ;-7-((Z);-3-((Carbamoyloxy);-2-(furan-2-yl)
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • ManufacturerSigma-Aldrich(India)
  • Product number34218
  • Product descriptionCefuroxime VETRANAL?, analytical standard
  • Packaging100MG
  • Price₹27841.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 34218 Cefuroxime VETRANAL?, analytical standard 100MG ₹27841.9 2022-06-14 Buy

Properties

Melting point :171.5-173°C
alpha :D20 +63.7° (c = 1.0 in 0.2M pH 7 phosphate buffer)
Density :1.76
refractive index :1.6000 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :pKa 2.5(H2O) (Uncertain)
form :Solid
color :White to Off-White
Water Solubility :145mg/L at 25℃
BCS Class :4
CAS DataBase Reference :55268-75-2(CAS DataBase Reference)
EPA Substance Registry System :5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)- (55268-75-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P285 In case of inadequate ventilation wear respiratory protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P321 Specific treatment (see … on this label).
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

As with the other cephalosporins, although as a second-generation variety, Cefuroxime is less susceptible to beta-lactamase. Hence, it may potentially have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae, and Lyme disease. Unlike most other second-generation cephalosporins, cefuroxime can cross the blood-brain barrier.

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