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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Estrogen and progestin drugs >Cyproterone acetate

Cyproterone acetate

Cyproterone acetate Structure
  • ₹9600 - ₹30970.33
  • Product name: Cyproterone acetate
  • CAS: 427-51-0
  • MF: C24H29ClO4
  • MW: 416.94
  • EINECS:207-048-3
  • MDL Number:MFCD00864671
  • Synonyms:cyprosteroneacetate ;1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio ;1,2-alpha-methylene-6-chloro-delta(sup6)-17-alpha-hydroxyprogesteroneacetat ;1,2-alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione17-alpha-acetate ;17-alpha-acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dio ;20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3 ;6)-pregnadiene-17-alpha-ol-3,20-dione17-2-alpha-methylene-6-chloro-(sup4 ;6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 50MG
  • 200MG
  • 250MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberC2942
  • Product descriptionCyproterone Acetate
  • Packaging200MG
  • Price₹9600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC2942
  • Product descriptionCyproterone Acetate
  • Packaging1G
  • Price₹12300
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3412
  • Product descriptionCyproterone acetate ≥98%
  • Packaging250MG
  • Price₹21303.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2809
  • Product descriptionCyproterone acetate Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material
  • Packaging50MG
  • Price₹30970.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C2942 Cyproterone Acetate 200MG ₹9600 2022-05-26 Buy
TCI Chemicals (India) C2942 Cyproterone Acetate 1G ₹12300 2022-05-26 Buy
Sigma-Aldrich(India) C3412 Cyproterone acetate ≥98% 250MG ₹21303.6 2022-06-14 Buy
Sigma-Aldrich(India) PHR2809 Cyproterone acetate Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material 50MG ₹30970.33 2022-06-14 Buy

Properties

Melting point :200-201°C
Boiling point :528.8°C (rough estimate)
Density :1.0677 (rough estimate)
refractive index :1.4429 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Practically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol.
form :Solid
color :White to Off-White
λmax :281nm(MeOH)(lit.)
Merck :14,2774
InChIKey :UWFYSQMTEOIJJG-KIXORDEXNA-N
SMILES :C[C@@]12C(=CC(=O)[C@@H]3C[C@H]13)C(Cl)=C[C@@]1([H])[C@]3([H])CC[C@@](C(=O)C)(OC(=O)C)[C@@]3(C)CC[C@]21[H] |&1:1,6,8,12,14,18,26,30,r|
EPA Substance Registry System :3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)- (427-51-0)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Cyproterone acetate (CPA) is a synthetic steroid that acts as an antagonist/partial agonist of the androgen receptor (IC50 = 26 nM in humans). Androgen receptor antagonists such as CPA have been shown to have clinical use in androgen-dependent conditions such as prostate cancer, hirsutism, and alopecia. However, high doses of CPA (10 mg/animal/day) can suppress accessory sexual glands and fertility in adult male rats. CPA promotes hepatomitogenic activity and has been reported to induce apoptosis of hepatocytes in rats at 0.3 μM after 72 hours exposure.

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Suppliers and manufacturers

Cipla Ltd BDR Pharmaceuticals International Pvt Ltd Swati Spentose Pvt Ltd Ralington Pharma PANCHSHEEL ORGANICS LTD CIPLA LIMITED A.J Chemicals CLEARSYNTH LABS LTD. Samchem India Private Limited Shaivya Pharmachem.