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DBCO-PEG5-NHS ester

DBCO-PEG5-NHS ester Structure
  • ₹0
  • Product name: DBCO-PEG5-NHS ester
  • CAS: 1378531-80-6
  • MF: C36H43N3O11
  • MW: 693.74
  • EINECS:
  • MDL Number:MFCD28334547
  • Synonyms:DBCO-PEG5-NHS ester;Azadibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester;DBCO-NH-PEG4-CH2CH2COONHS ester;DBCO-NHCO-PEG5-NHS ester;4,7,10,13,16-Pentaoxa-20-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-19,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.32±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Acetonitrile (Slightly), Chloroform (Slightly)
form :Oil
pka :15.14±0.46(Predicted)
color :Yellow to Dark Yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

DBCO-NHCO-PEG5-NHS ester is a PEG linker containing NHS ester that is able to react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and can also provide a long and flexible connection that minimizes steric hindrance during ligation. DBCO is commonly used for copper-free Click Chemistry reactions.

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