Isopropyl unoprostone
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- ₹0
- Product name: Isopropyl unoprostone
- CAS: 120373-24-2
- MF: C25H44O5
- MW: 424.61
- EINECS:1312995-182-4
- MDL Number:MFCD00886951
- Synonyms:RESCULA;UNOPROSTONE ISOPROPYL ESTER;isopropyl unoprostone;9ALPHA,11ALPHA-DIHYDROXY-15-OXO-20A,20B-DIHOMOPROST-5-EN-1-OIC ACID, ISOPROPYL ESTER;(5z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-5-heptenoic acid 1-methylethyl ester;13,14-dihydro-15-keto-20-ethyl-pgf;13,14-DIHYDRO-15-KETO-20-ETHYL PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER;(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopenthyl]-5-heptenoic Acid Isopropyl Ester
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Boiling point :546.3±45.0 °C(Predicted)
Density :1.019±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Oil
pka :14.79±0.70(Predicted)
color :Clear Colourless
CAS DataBase Reference :120373-24-2(CAS DataBase Reference)
Density :1.019±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Oil
pka :14.79±0.70(Predicted)
color :Clear Colourless
CAS DataBase Reference :120373-24-2(CAS DataBase Reference)
Safety Information
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Description
Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.Related product price
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