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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Endocrinology & Hormones >RAAS inhibitors >LCZ696

LCZ696

LCZ696 Structure
  • ₹0
  • Product name: LCZ696
  • CAS: 936623-90-4
  • MF: C48H58N6O8
  • MW: 847.03
  • EINECS:-0
  • MDL Number:MFCD29477717
  • Synonyms:[(C24H29N5O3).(C24H29NO5).2.5(H2O).3Na];LCZ696 ENTRESTO TM;LCZ696 Entresto;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate;Sacubitril mixture with Valsartan;Cocrystal of Sacubitril and Valsartan;(S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)hexanamido)-3-methylbutanoic acid;lcz696/Valsartan/sacubitril
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

storage temp. :Store at -20°C
solubility :≥45.05 mg/mL in DMSO; ≥11.28 mg/mL in H2O; ≥28.5 mg/mL in EtOH
form :solid
color :White to light yellow
InChIKey :XTKIDERFOUYBDE-NOFROVMTNA-N
SMILES :C(C1C=CC(C2C=CC=CC=2C2=NN=NN2)=CC=1)N(C(=O)CCCC)[C@H](C(=O)O)C(C)C.C(C1C=CC(C2C=CC=CC=2)=CC=1)[C@@H](NC(=O)CCC(=O)O)C[C@@H](C)C(=O)OCC |&1:25,45,55,r|

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan and AHU377 , a prodrug of LBQ657 , which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg/kg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure.

More related product prices

Valsartan (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid AHU-377 (heMicalciuM salt) (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate sacubitril AHU-377 (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid

Related product price

Suppliers and manufacturers

Bulat Pharmaceutical Pvt Ltd Viruj Pharmaceuticals Pvt Ltd Shree HariKrishna Pharmaceuticals Exemed Pharmaceuticals (Oneiro Chemicals Pvt Ltd) Blue Jet Healthcare Ltd LUPIN LTD CLEARSYNTH LABS LTD. Pharmaffiliates Analytics and Synthetics P. Ltd SynZeal Research Pvt Ltd Bulat Pharmaceutical Private Limited