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ChemicalBook > Product Catalogue >API >Antiallergic drugs >Antihistamines >Loratadine

Loratadine

Loratadine Structure
  • ₹3600 - ₹64679.38
  • Product name: Loratadine
  • CAS: 79794-75-5
  • MF: C22H23ClN2O2
  • MW: 382.88
  • EINECS:935-907-9
  • MDL Number:MFCD00672869
  • Synonyms:LORATADINE;LORATADINE-D5;4-(8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptene-5-ylidene)piperidine-1-carboxylic acid ethyl ester;4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine-11-ylidene)piperidine-1-carboxylic acid ethyl ester;Loratadine,4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine;anium wilfordii Maxim;4(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLATE;4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 100MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberL0223
  • Product descriptionLoratadine
  • Packaging100MG
  • Price₹3600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberL0223
  • Product descriptionLoratadine
  • Packaging1G
  • Price₹8600
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberL9664
  • Product descriptionLoratadine ≥98% (HPLC), powder
  • Packaging50MG
  • Price₹64679.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberL9664
  • Product descriptionLoratadine ≥98% (HPLC), powder
  • Packaging10MG
  • Price₹16183.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1376
  • Product descriptionLoratadine Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹11160.58
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) L0223 Loratadine 100MG ₹3600 2022-05-26 Buy
TCI Chemicals (India) L0223 Loratadine 1G ₹8600 2022-05-26 Buy
Sigma-Aldrich(India) L9664 Loratadine ≥98% (HPLC), powder 50MG ₹64679.38 2022-06-14 Buy
Sigma-Aldrich(India) L9664 Loratadine ≥98% (HPLC), powder 10MG ₹16183.38 2022-06-14 Buy
Sigma-Aldrich(India) PHR1376 Loratadine Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹11160.58 2022-06-14 Buy

Properties

Melting point :134-136°C
Boiling point :531.3±50.0 °C(Predicted)
Density :1.261±0.06 g/cm3(Predicted)
RTECS :TM6129200
storage temp. :2-8°C
solubility :DMSO: 26 mg/mL, soluble
form :powder
pka :4.27±0.20(Predicted)
color :white
Water Solubility :It is soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25°C), water (<1 mg/ml at 25°C), chloroform, and methanol.
Merck :14,5578
BCS Class :2
Stability :Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents.
InChIKey :JCCNYMKQOSZNPW-UHFFFAOYSA-N
CAS DataBase Reference :79794-75-5(CAS DataBase Reference)
EPA Substance Registry System :1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester (79794-75-5)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM). It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 μM) and histamine (IC50 = 11 μM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg.

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