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NAPHTHOFLUORESCEIN

NAPHTHOFLUORESCEIN Structure
  • ₹5239.2 - ₹21489.6
  • Product name: NAPHTHOFLUORESCEIN
  • CAS: 61419-02-1
  • MF: C28H16O5
  • MW: 432.42
  • EINECS:634-716-5
  • MDL Number:MFCD00329026
  • Synonyms:NAPHTHOFLUORESCEIN;NAPHTHOFLUORESCEIN, FOR FLUORESCENCE;NAPHTHOFLUORESCEIN FOR FLUORESCENCE 95+%;Naphthafluorescein;Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one,3,11-dihydroxy-
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • 500MG
  • ManufacturerSigma-Aldrich(India)
  • Product number70420
  • Product descriptionNaphthofluorescein suitable for fluorescence
  • Packaging100MG
  • Price₹5239.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number70420
  • Product descriptionNaphthofluorescein suitable for fluorescence
  • Packaging500MG
  • Price₹21489.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 70420 Naphthofluorescein suitable for fluorescence 100MG ₹5239.2 2022-06-14 Buy
Sigma-Aldrich(India) 70420 Naphthofluorescein suitable for fluorescence 500MG ₹21489.6 2022-06-14 Buy

Properties

Melting point :189 °C (dec.)(lit.)
Boiling point :755.5±60.0 °C(Predicted)
Density :1.58±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: soluble
form :A crystalline solid
pka :8.82±0.20(Predicted)
color :Purple to purplish red
BRN :61335
InChIKey :IXQIUDNVFVTQLJ-UHFFFAOYSA-N
EPA Substance Registry System :Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one, 3,11-dihydroxy- (61419-02-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase MT1-MMP, resulting in decreased levels of active MT1-MMP. This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP. Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080. The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.

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