NS 3694
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- ₹9570 - ₹33390
- Product name: NS 3694
- CAS: 426834-38-0
- MF: C15H10ClF3N2O3
- MW: 358.7
- EINECS:
- MDL Number:MFCD00249000
- Synonyms:Apoptosis Inhibitor II, NS3694;Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem;Benzoic acid, 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;NS 3694,Inhibitor,Apaf-1,Apoptosis,inhibit,caspase-9,NS-3694,apoptosome inhibitor,NS3694,cytochrome c
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberN7787
- Product descriptionNS3694 ≥98%, powder
- Packaging5MG
- Price₹9570
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number178494
- Product descriptionApoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibito
- Packaging10MG
- Price₹19050
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberN7787
- Product descriptionNS3694 ≥98%, powder
- Packaging25MG
- Price₹33390
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N7787 | NS3694 ≥98%, powder | 5MG | ₹9570 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 178494 | Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibito | 10MG | ₹19050 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N7787 | NS3694 ≥98%, powder | 25MG | ₹33390 | 2022-06-14 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO: 22 mg/mL, soluble
form :solid
color :Off-white to light yellow
solubility :DMSO: 22 mg/mL, soluble
form :solid
color :Off-white to light yellow
Safety Information
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Description
Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.Related product price
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