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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Angina Pectoris Drugs >Nicorandil

Nicorandil

Nicorandil Structure
  • ₹3996 - ₹35062.18
  • Product name: Nicorandil
  • CAS: 65141-46-0
  • MF: C8H9N3O4
  • MW: 211.17
  • EINECS:265-514-1
  • MDL Number:MFCD00186520
  • Synonyms:n-[2-(nitroxy)ethyl]-3-pyridinecarboxamide;N-[2-(NITROOXY)ETHYL]-3-PYRIDINECARBOXAMIDE;3-Pyridinecarboxamide, N-[2-(nitrooxy)ethyl]-;SG-75;Dancor;Nitric acid 2-nicotinoylaminoethyl ester;2-(pyridin-3-ylcarbonylamino)ethyl nitrate;2-(pyridine-3-carbonylamino)ethyl nitrate
Price8 Properties Safety Information Description
8 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 50MG
  • 100MG
  • 250MG
  • 1gm
  • 1G
  • 5gm
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberN0837
  • Product descriptionNicorandil
  • Packaging100MG
  • Price₹4000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberN0837
  • Product descriptionNicorandil
  • Packaging1G
  • Price₹8800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberN0837
  • Product descriptionNicorandil
  • Packaging5G
  • Price₹14500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN3539
  • Product descriptionNicorandil ≥98% (HPLC)
  • Packaging50MG
  • Price₹8746.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN3539
  • Product descriptionNicorandil ≥98% (HPLC)
  • Packaging250MG
  • Price₹35062.18
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number N 3526
  • Product descriptionNicorandil, ≥98% (HPLC)
  • Packaging100mg
  • Price₹3996
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number N 3526
  • Product descriptionNicorandil, ≥98% (HPLC)
  • Packaging1gm
  • Price₹8774
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number N 3526
  • Product descriptionNicorandil, ≥98% (HPLC)
  • Packaging5gm
  • Price₹14994
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) N0837 Nicorandil 100MG ₹4000 2022-05-26 Buy
TCI Chemicals (India) N0837 Nicorandil 1G ₹8800 2022-05-26 Buy
TCI Chemicals (India) N0837 Nicorandil 5G ₹14500 2022-05-26 Buy
Sigma-Aldrich(India) N3539 Nicorandil ≥98% (HPLC) 50MG ₹8746.6 2022-06-14 Buy
Sigma-Aldrich(India) N3539 Nicorandil ≥98% (HPLC) 250MG ₹35062.18 2022-06-14 Buy
ottokemi N 3526 Nicorandil, ≥98% (HPLC) 100mg ₹3996 2022-05-26 Buy
ottokemi N 3526 Nicorandil, ≥98% (HPLC) 1gm ₹8774 2022-05-26 Buy
ottokemi N 3526 Nicorandil, ≥98% (HPLC) 5gm ₹14994 2022-05-26 Buy

Properties

Melting point :92°C
Boiling point :350.85°C (rough estimate)
Density :1.4271 (rough estimate)
refractive index :1.7400 (estimate)
RTECS :US4667600
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
pka :12.70±0.46(Predicted)
form :powder
color :white to off-white
Merck :14,6521
CAS DataBase Reference :65141-46-0

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H242 Heating may cause a fire Self-reactive substances and mixtures; and Organic peroxides Type C, D,Type E, F
Type G		 Danger
Warning		 GHS hazard pictograms P210, P220, P234, P280, P370+P378,P403+P235, P411, P420, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P235 Keep cool.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P370+P378 In case of fire: Use … for extinction.
P410 Protect from sunlight.

Description

Nicorandil is a nicotinamide-nitric oxide ester with vasodilatory and cardioprotective effects. It is best known as a potassium channel activator that targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (EC50 = 10 μM). In addition to driving dilation of peripheral and coronary arterioles, K+ channel activation by nicorandil delays the induction of mitochondrial permeability transition in response to oxidative stress. Nicorandil can also act as a nitric oxide donor, increasing intracellular cGMP production leading to venodilation and pain suppression.

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