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OLDA

OLDA Structure
  • ₹0
  • Product name: OLDA
  • CAS: 105955-11-1
  • MF: C26H43NO3
  • MW: 417.62
  • EINECS:
  • MDL Number:MFCD05665144
  • Synonyms:(9Z)-N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]-9-OCTADECENAMIDE;N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]9Z-OCTADECENAMIDE;OLDA;ODA;N-OLEOYLDOPAMINE;N-Oleoyldopamine (OLDA);(Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide;9-Octadecenamide, N-[2-(3,4-dihydroxyphenyl)ethyl]-, (9Z)-
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :60-61oC
Boiling point :619.5±55.0 °C(Predicted)
Density :1.004±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: ~20 mg/mL, soluble
form :powder
pka :9.79±0.10(Predicted)
color :white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

N-Oleoyl dopamine (ODA) is a selective, endogenous vanilloid receptor 1 (VR1) agonist isolated from bovine brain. Structurally, it is the amide of oleic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. ODA binds to the human recombinant VR1 with a Ki of 36 nM making it equipotent to capsaicin and slightly more potent than N-arachidonoyl dopamine in this assay. It causes hyperalgesia and nocifensive behavior that is blocked by the VR1 antagonist iodo-resiniferatoxin. ODA is selective for VR1 based on observations that it has weak affinity for the rat CB1 receptor (Ki of 1.6 μM) and is a very weak inhibitor of FAAH. ODA is also a potent inhibitor of 5-lipoxygenase from rat basophilic leukemia-1 (RBL-1) cells, with a IC50 of 7.5 nM.

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Suppliers and manufacturers

Aladdin Scientific Shanghai Aladdin Biochemical Technology Co.,Ltd. RD International Technology Co., Limited Bide Pharmatech Ltd. Jinan Jiuli Biotechnology Co. , Ltd. Alexis Corporation Service Chemical Inc. BIOTREND Chemicals AG AXXORA, LLC 3B Scientific Corporation