storage temp. :Store at -20°C solubility :≥88.6 mg/mL in DMSO; ≥2.15 mg/mL in EtOH with gentle warming and ultrasonic; ≥2.1 mg/mL in H2O with gentle warming and ultrasonic form :crystalline solid color :Off-white to light yellow
Safety Information
Symbol(GHS):
Signal word:
Warning
Hazard statements:
Code
Hazard statements
Hazard class
Category
Signal word
Pictogram
P-Codes
H302
Harmful if swallowed
Acute toxicity,oral
Category 4
Warning
P264, P270, P301+P312, P330, P501
H315
Causes skin irritation
Skin corrosion/irritation
Category 2
Warning
P264, P280, P302+P352, P321,P332+P313, P362
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Category 2A
Warning
P264, P280, P305+P351+P338,P337+P313P
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure;Respiratory tract irritation
Category 3
Warning
Precautionary statements:
P261
Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.
