Otilonium bromide
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- ₹10792.53 - ₹43505.68
- Product name: Otilonium bromide
- CAS: 26095-59-0
- MF: C29H43BrN2O4
- MW: 563.58
- EINECS:247-457-4
- MDL Number:MFCD00211142
- Synonyms:Menoctyl;N,N-Diethyl-N-methy-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]ethanaminium Bromide;Pasminox;SP-63;Spasen;Spasmoctyl;Spasmome;OTYLONIUMBROMIDE
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1454
- Product descriptionOtilonium bromide ≥98% (HPLC)
- Packaging5MG
- Price₹10792.53
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1454
- Product descriptionOtilonium bromide ≥98% (HPLC)
- Packaging25MG
- Price₹43505.68
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1454 | Otilonium bromide ≥98% (HPLC) | 5MG | ₹10792.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1454 | Otilonium bromide ≥98% (HPLC) | 25MG | ₹43505.68 | 2022-06-14 | Buy |
Properties
Melting point :130-133°C
storage temp. :-20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :powder
color :white to beige
CAS DataBase Reference :26095-59-0(CAS DataBase Reference)
storage temp. :-20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :powder
color :white to beige
CAS DataBase Reference :26095-59-0(CAS DataBase Reference)
Safety Information
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Description
Otilonium is an inhibitor of L-type (IC50 = 2.3 μM) and T-type calcium channels (IC50s = 0.8, 1.1, and 0.4 μM for Cav3.1, Cav3.2, and Cav3.3, respectively). It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.054, 0.4, 0.222, and 0.156 μM for M1, M2, M4, and M5 muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC50 = 0.0552 μM). Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC50 = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine . It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC50 = 3.7 μM). Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.More related product prices
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₹790-41156.65
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