PENICILLIC ACID
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- Product name: PENICILLIC ACID
- CAS: 90-65-3
- MF: C8H10O4
- MW: 170.16
- EINECS:202-008-1
- MDL Number:MFCD00004365
- Synonyms:3-METHOXY-5-METHYL-4-OXO-2,5-HEXADIENOIC ACID;3-methoxy-5-methyl-4-oxo-5-hexadienoicacid ;gamma-keto-beta-methoxy-delta-methylene-delta(supalpha)-hexenoicacid ;kyselinapenicilova ;pencillicacid ;PENICILLIC ACID;3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid ;PENICILLIC ACID 99%
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Properties
Melting point :83-87 °C
Boiling point :219.79°C (rough estimate)
Density :1.1456 (rough estimate)
refractive index :1.4425 (estimate)
storage temp. :Store at 2-8
solubility :DMSO: >10mg/mL
pka :3.90±0.33(Predicted)
form :solid
color :Needles from pet ether or rhombic orhexagonal plates
Merck :13,7163
CAS DataBase Reference :90-65-3
IARC :3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System :Penicillic acid (90-65-3)
Boiling point :219.79°C (rough estimate)
Density :1.1456 (rough estimate)
refractive index :1.4425 (estimate)
storage temp. :Store at 2-8
solubility :DMSO: >10mg/mL
pka :3.90±0.33(Predicted)
form :solid
color :Needles from pet ether or rhombic orhexagonal plates
Merck :13,7163
CAS DataBase Reference :90-65-3
IARC :3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System :Penicillic acid (90-65-3)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Gram negative bacteria utilize N-acylated homoserine lactones to coordinate expression of virulence in response to the density of the surrounding bacterial population in a process termed quorum sensing. By interfering with this communication and thereby disrupting virulence expression, quorum sensing inhibitors are emerging as an alternative to the conventional ways of fighting bacterial infections. Penicillic acid is a mycotoxin produced from Penicillium species identified in molds on corn and other grains. At 80 μM, penicillic acid inhibits bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes. It has been shown to inhibit Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.Related product price
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Suppliers and manufacturers
SynZeal Research Pvt Ltd
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Shenzhen Excellent Biomedical Technology Co.,Ltd.
China National Standard Pharmaceutical Corporation Limited
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
Wuhan Huangzhen Biochemical Co., Ltd
Shanghai Aladdin Biochemical Technology Co.,Ltd.
