Plerixafor
- ₹0
- Product name: Plerixafor
- CAS: 1246819-87-3
- MF: C28H54N8
- MW: 502.78196
- EINECS:
- MDL Number:MFCD19705148
- Synonyms:Plerixafor-d4;[2H4]-Plerixafor;Paclobutrazol Impurity 6
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Properties
Melting point :100-102°C
storage temp. :Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility :DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
form :Solid
color :White to Light Yellow
Stability :Very Hygroscopic
storage temp. :Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility :DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
form :Solid
color :White to Light Yellow
Stability :Very Hygroscopic
Safety Information
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Description
Plerixafor-d4 is intended for use as an internal standard for the quantification of plerixafor by GC- or LC-MS. Plerixafor is a partial antagonist of chemokine receptor 4 (CXCR4) with IC50 values ranging from 0.02 to 0.13 μg/ml for inhibiting calcium flux in peripheral blood mononuclear cells (PBMCs), various types of T cells, and mouse lymphocytic leukemia cells. It is selective for CXCR4 over CXCR1-3 and CXCR5-9 (IC50s = >25 μg/ml). Plerixafor decreases infectious virus content in the supernatant of Jurkat cells chronically infected with HIV-1(IIIB) (EC50 = ~0.02 μg/ml). It rapidly mobilizes murine and human hematopoietic stem and murine long-term repopulating cells for transplantation alone and, with a synergistic effect, when used in combination with G-CSF. Plerixafor also increases T cell trafficking in mouse blood, spleen, and central nervous system. Plerixafor (1.25 mg/kg twice per day) decreases the number of 4T1 murine mammary carcinoma cells in the lung in a mouse model of lung metastasis.More related product prices
PLERIXAFORRelated product price
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