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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >SGX-523

SGX-523

SGX-523 Structure
  • ₹15469.99
  • Product name: SGX-523
  • CAS: 1022150-57-7
  • MF: C18H13N7S
  • MW: 359.41
  • EINECS:-0
  • MDL Number:MFCD16660190
  • Synonyms:SGX-523;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline;SGX 523(SGX-523);Quinoline,6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline SGX 523;SGX-523, >=98%;6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline;SGX-523;SGX523; SGX 523
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number448106
  • Product descriptionMet Kinase Inhibitor VI, SGX523 - CAS 1022150-57-7 - Calbiochem The Met Kinase Inhibitor VI, SGX523, also referenced under CAS 1022150-57-7, controls the biological activity of Met Kinase. This small molecule/inhib
  • Packaging5MG
  • Price₹15469.99
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 448106 Met Kinase Inhibitor VI, SGX523 - CAS 1022150-57-7 - Calbiochem The Met Kinase Inhibitor VI, SGX523, also referenced under CAS 1022150-57-7, controls the biological activity of Met Kinase. This small molecule/inhib 5MG ₹15469.99 2022-06-14 Buy

Properties

Density :1.485
storage temp. :Store at -20°C
solubility :≥17.95 mg/mL in DMSO
pka :3.94±0.10(Predicted)
form :solid
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
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Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
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Description

The hepatocyte growth factor receptor c-Met commonly shows elevated activity in several forms of cancer. SGX523 is a potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC50 value of 4 nM. It is over 1,000-fold selective for c-Met over a panel of other kinases. SGX523 is orally active and dose-dependently inhibits the growth of a variety of tumor xenografts in mice. The effectiveness of SGX523 is enhanced when combined with other chemotherapeutic compounds, including inhibitors of EGFR. SGX523 is metabolized, at least in part, by aldehyde oxidase, an enzyme that differs in activity across different species.