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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Erectile Dysfunction Treatment >Tadalafil

Tadalafil

Tadalafil Structure
  • ₹7934.73 - ₹26748.58
  • Product name: Tadalafil
  • CAS: 171596-29-5
  • MF: C22H19N3O4
  • MW: 389.4
  • EINECS:687-782-2
  • MDL Number:MFCD07771966
  • Synonyms:ICOS 351;UK 336017;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;Cialis ,98%;Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-
Price5 Properties Safety Information Description
5 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 20MG
  • 50MG
  • 500MG
  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1877
  • Product descriptionTadalafil ≥98% (HPLC)
  • Packaging10MG
  • Price₹7934.73
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1810
  • Product descriptionTadalafil Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹16215.85
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT-072
  • Product descriptionTadalafil solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹16837.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberNMID941
  • Product descriptionTadalafil
  • Packaging20MG
  • Price₹25536.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1877
  • Product descriptionTadalafil ≥98% (HPLC)
  • Packaging50MG
  • Price₹26748.58
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1877 Tadalafil ≥98% (HPLC) 10MG ₹7934.73 2022-06-14 Buy
Sigma-Aldrich(India) PHR1810 Tadalafil Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹16215.85 2022-06-14 Buy
Sigma-Aldrich(India) T-072 Tadalafil solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹16837.8 2022-06-14 Buy
Sigma-Aldrich(India) NMID941 Tadalafil 20MG ₹25536.18 2022-06-14 Buy
Sigma-Aldrich(India) SML1877 Tadalafil ≥98% (HPLC) 50MG ₹26748.58 2022-06-14 Buy

Properties

Melting point :298-300°C
alpha :D20 +71.0°
Boiling point :679.1±55.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :16.68±0.40(Predicted)
color :white to beige
optical activity :[α]/D +68 to +78°, c = 1 in chloroform-d
BCS Class :4
Stability :Unstable in Methanol
InChI :InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
InChIKey :WOXKDUGGOYFFRN-IIBYNOLFSA-N
SMILES :N1C2=C(C=CC=C2)C2C[C@]3([H])C(=O)N(C)CC(=O)N3[C@H](C3=CC=C4OCOC4=C3)C1=2
CAS DataBase Reference :171596-29-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.

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