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ChemicalBook > Product Catalogue >API >Specialty drugs >Ophthalmic drugs >Tropicamide

Tropicamide

Tropicamide Structure
  • ₹8356.9 - ₹27668.7
  • Product name: Tropicamide
  • CAS: 1508-75-4
  • MF: C17H20N2O2
  • MW: 284.35
  • EINECS:216-140-2
  • MDL Number:MFCD00058580
  • Synonyms:Tropicamide (200 mg);(2R)-N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylMethyl)propanaMide;TropicaMide N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylMethyl)propanaMide;Tropicamide for peak identification;n-ethyl-2-phenyl-n-(4-pyridylmethyl)-hydracrylamid ;N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide;n-ethyl-alpha-(hydroxymethyl)-n-(4-pyridinylmethyl)-benzeneacetamid ;ro1-7683
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 500MG
  • 1G
  • 10G
  • ManufacturerTCI Chemicals (India)
  • Product numberT1470
  • Product descriptionTropicamide
  • Packaging10G
  • Price₹9900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT9778
  • Product descriptionTropicamide solid
  • Packaging100MG
  • Price₹8356.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR3152
  • Product descriptionTropicamide pharmaceutical secondary standard, certified reference material
  • Packaging500MG
  • Price₹15912.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT9778
  • Product descriptionTropicamide solid
  • Packaging1G
  • Price₹27668.7
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T1470 Tropicamide 10G ₹9900 2022-05-26 Buy
Sigma-Aldrich(India) T9778 Tropicamide solid 100MG ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) PHR3152 Tropicamide pharmaceutical secondary standard, certified reference material 500MG ₹15912.75 2022-06-14 Buy
Sigma-Aldrich(India) T9778 Tropicamide solid 1G ₹27668.7 2022-06-14 Buy

Properties

Melting point :98 °C
Boiling point :492.8±45.0 °C(Predicted)
Density :1.161±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL
form :solid
pka :pKa 5.3 (Uncertain)
color :white
Water Solubility :0.2g/L(25 ºC)
λmax :254nm(HCl aq.)(lit.)
Merck :14,9780
InChI :InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChIKey :BGDKAVGWHJFAGW-UHFFFAOYSA-N
SMILES :C(CO)(C(=O)N(CC)CC1=CC=NC=C1)C1C=CC=CC=1
CAS DataBase Reference :1508-75-4(CAS DataBase Reference)
NIST Chemistry Reference :Tropicamide(1508-75-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction. Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in chicken heart) that displays 3-fold selectivity for M4. When applied as eye drops, it produces temporary mydriasis (pupil dilation; EC50 = 6 μg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 μg/ml). Tropicamide has been used to probe mAChR activity in a mouse model of fragile X syndrome.

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