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Vipadenant

Vipadenant Structure
  • ₹0
  • Product name: Vipadenant
  • CAS: 442908-10-3
  • MF: C16H15N7O
  • MW: 321.34
  • EINECS:
  • MDL Number:MFCD12024697
  • Synonyms:Vipadenant(BIIB 014);3-[(4-Amino-3-methylphenyl)methyl]-7-(2-furanyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine;CEB 4520;V 2006;VER 11135;VER-A 00049;VER-A 00-11;VER-ADO 49
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :245.3-246.1 °C
Boiling point :668.5±65.0 °C(Predicted)
Density :1.56±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:37.0(Max Conc. mg/mL);115.14(Max Conc. mM)
form :A crystalline solid
pka :4.27±0.30(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Vipadenant (also known as BIIB014) is a potent, selective oral adenosine A2A receptor antagonist under development for the treatment of Parkinson’s disease. It has successfully completed phase I clinical studies. It might also be a potential adjunctive therapy reagent for cancer treatment. It was found that it has certain potentials to disrupt an immunosuppressive mechanism of tumour protection, generating improved efficacy for immunotherapies of certain cancers when used in combination with other drugs.

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