WYE 354-d3
|
- ₹0
- Product name: WYE 354-d3
- CAS: 1794791-66-4
- MF: C24H29N7O5
- MW: 495.54
- EINECS:
- MDL Number:
- Synonyms:WYE 354-d3;4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.Related product price
- WYE-354
₹26250
Suppliers and manufacturers
CLEARSYNTH LABS LTD.
Toronto Research Chemicals
Xiamen Research Biotechnology Co., Ltd.
Shanghai Ziqi Biological Technology Co., Ltd.
Shanghai Yubo Biotechnology Co., Ltd.
Xiamen Huijia Biological Technology Co., Ltd.
Shanghai Hao Zhun Biological Technology Co., Ltd.
Shanghai Hao Biological Technology Co., Ltd.
Energy Chemical