YS121
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- ₹0
- Product name: YS121
- CAS: 916482-17-2
- MF: C20H26ClN3O2S
- MW: 407.96
- EINECS:
- MDL Number:MFCD18382121
- Synonyms:YS121;HVJBWTVMRIOTEL-UHFFFAOYSA-N;YS121 Exclusive;Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
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Properties
Boiling point :557.4±50.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka :3.04±0.21(Predicted)
form :solution in acetate.
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka :3.04±0.21(Predicted)
form :solution in acetate.
Safety Information
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| Signal word: | Danger | |||||||
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Description
Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM) and 5-LO (IC50 = 4.1 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.Suppliers and manufacturers
ApexBio Technology
Shanghai Benrui Biotechnology Co., Ltd.
Shanghai Minmin Biotechnology Co., Ltd.
Resenbio
Shanghai Chaoyan Biotechnology Co., Ltd.
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Beijing Baiao Innovation Technology Co., Ltd.
Boao Pike
Shanghai Yaoyun Biological Technology Co., Ltd.
