ZEBULARINE
|
- ₹8500 - ₹50758.43
- Product name: ZEBULARINE
- CAS: 3690-10-6
- MF: C9H12N2O5
- MW: 228.2
- EINECS:2017-001-1
- MDL Number:MFCD04973699
- Synonyms:4-Deoyuridine;1-b-D-ribofuranosyl-2-(1H)-pyriMidinone;anticancer drug, DNA Methylation inhibitor;2(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-;2-Pyrimidone-1-β-D-riboside;1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone;Pyrimidin-2-one beta-D-ribofuranoside;1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one
6 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- 200MG
- 1G
- ManufacturerTCI Chemicals (India)
- Product numberZ0022
- Product descriptionZebularine
- Packaging200MG
- Price₹8500
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberZ0022
- Product descriptionZebularine
- Packaging1G
- Price₹14800
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberZ4775
- Product descriptionZebularine ≥98% (HPLC), solid
- Packaging5MG
- Price₹12535.35
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number691400
- Product descriptionZebularine - CAS 3690-10-6 - Calbiochem A cell-permeable chemically stable cytidine analog that displays antitumor properties.
- Packaging10MG
- Price₹19050
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number691400
- Product descriptionZebularine - CAS 3690-10-6 - Calbiochem A cell-permeable chemically stable cytidine analog that displays antitumor properties.
- Packaging25MG
- Price₹44200.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberZ4775
- Product descriptionZebularine ≥98% (HPLC), solid
- Packaging25MG
- Price₹50758.43
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | Z0022 | Zebularine | 200MG | ₹8500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | Z0022 | Zebularine | 1G | ₹14800 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | Z4775 | Zebularine ≥98% (HPLC), solid | 5MG | ₹12535.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 691400 | Zebularine - CAS 3690-10-6 - Calbiochem A cell-permeable chemically stable cytidine analog that displays antitumor properties. | 10MG | ₹19050 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 691400 | Zebularine - CAS 3690-10-6 - Calbiochem A cell-permeable chemically stable cytidine analog that displays antitumor properties. | 25MG | ₹44200.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | Z4775 | Zebularine ≥98% (HPLC), solid | 25MG | ₹50758.43 | 2022-06-14 | Buy |
Properties
Melting point :160-162?C
Boiling point :499.0±55.0 °C(Predicted)
Density :1.73±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
form :solid
pka :13.48±0.70(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey :RPQZTTQVRYEKCR-WCTZXXKLSA-N
Boiling point :499.0±55.0 °C(Predicted)
Density :1.73±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
form :solid
pka :13.48±0.70(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey :RPQZTTQVRYEKCR-WCTZXXKLSA-N
Safety Information
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Description
Zebularine, a cytidine analog, is a DNA methylation inhibitor that acts by forming a covalent complex with DNA methyltransferases (DNMTs). By stabilizing the binding of DNMTs to DNA, zebularine hinders methylation and decreases dissociation, trapping DNMT and preventing its turnover. Zebularine preferentially targets cancer cells in various human carcinoma cell lines demonstrating IC20 values of 20, 10, 20, and 5 μM for reducing proliferation of TK6, Jurkat, KG-1, and HCT116 cells, respectively. Zebularine exhibits low toxicity in mice even after prolonged administration (0.2 mg/mL drinking water for 113 days in a mouse intestinal cancer model).More related product prices
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