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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Cbz-amino acid >ZPCK

ZPCK

ZPCK Structure
  • ₹12686.9
  • Product name: ZPCK
  • CAS: 26049-94-5
  • MF: C18H18ClNO3
  • MW: 331.79
  • EINECS:247-432-8
  • MDL Number:MFCD00037114
  • Synonyms:SL-01;carbamicacid,[3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester,(s ;(S)-benzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate;N-CBZ-L-PHENYLALANINE CHLOROMETHYL*KETON E;z-l-phe chloromethyl ketone;(S)-Penzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate.;ZPCK, N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone;(3S)-1-Chloro-3-(benzyloxycarbonylamino)-4-phenyl-2-butanone
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product number860794
  • Product descriptionZ-L-Phe chloromethyl ketone 98%
  • Packaging1G
  • Price₹12686.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 860794 Z-L-Phe chloromethyl ketone 98% 1G ₹12686.9 2022-06-14 Buy

Properties

Melting point :107-108 °C(lit.)
Boiling point :503.1±50.0 °C(Predicted)
Density :1.1630 (rough estimate)
refractive index :1.6470 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
form :solid
pka :10.74±0.46(Predicted)
color :White
optical activity :[α]23/D +30°, c = 1 in chloroform
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference :26049-94-5
EPA Substance Registry System :Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363 Wash contaminated clothing before reuse.

Description

SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.

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