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ChemicalBook > Product Catalogue >API >Specialty drugs >Dermatology drugs >Adapalene

Adapalene

Adapalene Structure
  • ₹4000 - ₹21790.73
  • Product name: Adapalene
  • CAS: 106685-40-9
  • MF: C28H28O3
  • MW: 412.52
  • EINECS:620-513-9
  • MDL Number:MFCD03106112
  • Synonyms:ADAPALENE;6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID;6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid;CD-271;Differi;6-[4-Methoxy-3-(adamantan-1-yl)phenyl]-2-naphthalenecarboxylic acid;6-[3-(adaMantan-1-yl)-4-Methoxyphenyl]naphthalene-2-carboxylic acid;[1]6-[4-Methoxy-3-(tricyclo[3.3.1.1~3,7~]dec-1-yl)phenyl]naphthalene-2-carboxylic acid
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 25MG
  • 50MG
  • 200MG
  • 500MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberA2549
  • Product descriptionAdapalene
  • Packaging200MG
  • Price₹4000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2549
  • Product descriptionAdapalene
  • Packaging1G
  • Price₹14500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number114825-M
  • Product descriptionAdapalene - CAS 106685-40-9 - Calbiochem A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα.
  • Packaging25MG
  • Price₹6990
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA7486
  • Product descriptionAdapalene ≥98% (HPLC)
  • Packaging10MG
  • Price₹8746.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1388
  • Product descriptionAdapalene Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹10835.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA7486
  • Product descriptionAdapalene ≥98% (HPLC)
  • Packaging50MG
  • Price₹21790.73
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) A2549 Adapalene 200MG ₹4000 2022-05-26 Buy
TCI Chemicals (India) A2549 Adapalene 1G ₹14500 2022-05-26 Buy
Sigma-Aldrich(India) 114825-M Adapalene - CAS 106685-40-9 - Calbiochem A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα. 25MG ₹6990 2022-06-14 Buy
Sigma-Aldrich(India) A7486 Adapalene ≥98% (HPLC) 10MG ₹8746.6 2022-06-14 Buy
Sigma-Aldrich(India) PHR1388 Adapalene Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹10835.83 2022-06-14 Buy
Sigma-Aldrich(India) A7486 Adapalene ≥98% (HPLC) 50MG ₹21790.73 2022-06-14 Buy

Properties

Melting point :319-3220C
Boiling point :606.3±55.0 °C(Predicted)
Density :1.233±0.06 g/cm3(Predicted)
RTECS :QJ1987000
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
pka :4.2(at 25℃)
form :White solid
color :white to off-white
Merck :14,150
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months
InChIKey :LZCDAPDGXCYOEH-UHFFFAOYSA-N
SMILES :C1=C2C(C=C(C3=CC=C(OC)C(C45CC6CC(CC(C6)C4)C5)=C3)C=C2)=CC=C1C(O)=O
CAS DataBase Reference :106685-40-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Adapalene, a synthetic naphthoic acid derivative, is a selective agonist of retinoic acid receptor (RAR)-β and RAR-γ (Kds = 34 and 130 nM, respectively). At 0.1-10 μM, adapalene dose-dependently inhibits sebocyte growth, proliferation, and differentiation in a primary rat preputial cell culture system. Adapalene demonstrates anti-inflammatory and immunomodulatory activity by inhibiting 5-lipoxygenase-catalyzed leukotriene production and expression of toll-like receptor 2 on human monocytes. It is commonly used for the study of the pathogenesis and treatment of acne vulgaris.

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Suppliers and manufacturers

NILKANTH HEALTH CHEM (I) PRIVATE LIMITED SEUTIC Zuhhad international Hem-Deep Organics Pvt. Ltd. (HOPL) Aarti Industries Limited (AIL) Dayaram Pharma Chem Glenmark Pharmaceuticals Limited Paradise Healthcare Rivashaa Agrotech Biopharma Pvt. Ltd. Prachin Chemicals Saykha Private Limited