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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Hormonal antineoplastic drugs >Anastrozole

Anastrozole

Anastrozole Structure
  • ₹10695.1 - ₹42325.75
  • Product name: Anastrozole
  • CAS: 120511-73-1
  • MF: C17H19N5
  • MW: 293.37
  • EINECS:601-715-6
  • MDL Number:MFCD00866298
  • Synonyms:ICI-D-1033;1-[3,5-DI-(1-METHYL-1-CYANO)-ETHYL]-BENZYL-1,2,4-TRIAZOLE;α，α，α’，α'-Tetramethyl-5-(1H-1，2，4-triazol-1-ylmethyl)-1，3-benzenediacetonitrile;2-[3-(2-Cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile;α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile;Anastrozole(AriMidex);Anastrozole (200 mg);2-[3-(1-cyano-1-Methylethyl)-5-(1H-1,2,4-triazol-1-ylMethyl)phenyl]-2-Methylpropanenitrile
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 500MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberA2736
  • Product descriptionAnastrozole ≥98% (HPLC)
  • Packaging50MG
  • Price₹42325.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1783
  • Product descriptionAnastrozole Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹32442.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA2736
  • Product descriptionAnastrozole ≥98% (HPLC)
  • Packaging10MG
  • Price₹10695.1
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A2736 Anastrozole ≥98% (HPLC) 50MG ₹42325.75 2022-06-14 Buy
Sigma-Aldrich(India) PHR1783 Anastrozole Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹32442.53 2022-06-14 Buy
Sigma-Aldrich(India) A2736 Anastrozole ≥98% (HPLC) 10MG ₹10695.1 2022-06-14 Buy

Properties

Melting point :81-82°C
Boiling point :469.7±55.0 °C(Predicted)
Density :1.08±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble40mg/mL
pka :2.62±0.10(Predicted)
form :solid
color :White to off-white
BCS Class :1 (LogP), 3 (CLogP)
InChI :InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3
InChIKey :YBBLVLTVTVSKRW-UHFFFAOYSA-N
SMILES :C(#N)C(C1=CC(CN2C=NC=N2)=CC(C(C#N)(C)C)=C1)(C)C
CAS DataBase Reference :120511-73-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Anastrozole is a third generation aromatase inhibitor that has been shown to effectively eliminate the conversion of androgens to estrogens in peripheral tissues. It inhibits human placental aromatase in vitro with an IC50 value of 15 nM and at doses 100–200 times its maximally effective aromatase inhibitory dose, does not interfere with the biosynthesis of other steroids, including cholesterol, cortisol, and aldosterone. Marketed under the trade name Arimidex?, anastrozole has been used to treat estrogen receptor-positive breast cancers in post-menopausal women.

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Suppliers and manufacturers

Jigs Chemical ltd AVD pharmaceuticals Pvt Ltd SGMR PHARMACEUTICALS PVT LTD Anant Pharmaceuticals Pvt Ltd GLP Pharma Standards Apotex Pharmachem India Pvt Ltd Cipla Ltd Hetero Drugs Limited Sun Pharmaceutical Industries Ltd Chorus Labs Limited