APICIDIN
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- ₹13726.1 - ₹44285.08
- Product name: APICIDIN
- CAS: 183506-66-3
- MF: C34H49N5O6
- MW: 623.78
- EINECS:
- MDL Number:MFCD26142628
- Synonyms:APICIDIN, FUSARIUM SPECIES;Ccris 9163;Apicidin Ia;Cyclo(8-oxo-L-2-aMinodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl);Cyclo[(2S)-2-aMino-8-oxodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl];OSI 2040;Apicidin Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl];CYCLO-L-(2-AMINO-8-OXODEACANOYL)-L-(N-METHOXY-TRYPTOPHAN)-L-ISOLEUCYL-D-PIPECOLINYL
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberA8851
- Product descriptionApicidin ≥98% (HPLC), from microbial
- Packaging1MG
- Price₹13726.1
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberA8851
- Product descriptionApicidin ≥98% (HPLC), from microbial
- Packaging5MG
- Price₹44285.08
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A8851 | Apicidin ≥98% (HPLC), from microbial | 1MG | ₹13726.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A8851 | Apicidin ≥98% (HPLC), from microbial | 5MG | ₹44285.08 | 2022-06-14 | Buy |
Properties
Melting point :188-190oC
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: ~1mg/mL
pka :13.09±0.70(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. Compound is prone to oxidation. Protect from exposure to air.
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: ~1mg/mL
pka :13.09±0.70(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. Compound is prone to oxidation. Protect from exposure to air.
Safety Information
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Description
Histone acetyltransferase and histone deacetylase (HDAC) activity regulates the reversible acetylation of lysine residues within histone tails, which results in either transcriptional activation or repression of nearby genes. Compounds that modulate this activity are of interest in cancer chemotherapeutics as well as for treating psychiatric disorders, malaria, and other diseases. Apicidin is a fungal toxin that has broad spectrum activity against Apicomplexan parasites through inhibiting HDACs (IC50 = 0.7 nM). An in vitro activity assay demonstrates apicidin inhibition of HDAC3/NcoR, a class I HDAC, at a much higher potency than for class II HDAC6 (IC50s = 15.8 and 665.1 nM, respectively). Apicidin exhibits antiproliferative activity against various cancer cell lines (IC50s = 0.13-2.36 μM), and at 0.5 – 2 μM it induces selective changes in p21WAF1/Cip1 and gelsolin gene expression, which control cell cycle and cell morphology, respectively.Related product price
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