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ChemicalBook > Product Catalogue >Natural Products >Terpenes >Atractylenolide-1

Atractylenolide-1

Atractylenolide-1 Structure
  • ₹20145.33 - ₹67764.5
  • Product name: Atractylenolide-1
  • CAS: 73069-13-3
  • MF: C15H18O2
  • MW: 230.3
  • EINECS:
  • MDL Number:MFCD09037395
  • Synonyms:ATRACTYLENOLIDE-1;3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one;Eudesma-4(15),7(11),8-trien-12-olide;8,9-Dehydroasterolide;(4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one;Atractylenolide Ⅰ;Atractylenolide I, >99%;Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberA2737
  • Product descriptionAtractylenolide I ≥98% (HPLC)
  • Packaging10MG
  • Price₹20145.33
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA2737
  • Product descriptionAtractylenolide I ≥98% (HPLC)
  • Packaging50MG
  • Price₹67764.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A2737 Atractylenolide I ≥98% (HPLC) 10MG ₹20145.33 2022-06-14 Buy
Sigma-Aldrich(India) A2737 Atractylenolide I ≥98% (HPLC) 50MG ₹67764.5 2022-06-14 Buy

Properties

Melting point :121-123 °C(Solv: ligroine (8032-32-4))
Boiling point :405.0±44.0 °C(Predicted)
Density :1.12
Flash point :170℃
storage temp. :2-8°C
solubility :methanol: soluble1mg/mL, clear, colorless
form :powder
color :White
InChIKey :ZTVSGQPHMUYCRS-SWLSCSKDSA-N

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
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Description

Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.

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