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CA-074 ME

CA-074 ME Structure
  • ₹41221.6
  • Product name: CA-074 ME
  • CAS: 147859-80-1
  • MF: C19H31N3O6
  • MW: 397.47
  • EINECS:
  • MDL Number:MFCD00797532
  • Synonyms:N-(L-3-TRANS-PROPYLCARBONYL-OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE METHYL ESTER;L-trans-Epoxysuccinyl(propylamide)-Ile-P;(L-3-Trans-(propylcarbamoyl)oxirane-2-carbony;L-trans-Epoxysuccinic Ile-Pro-OMe Propylamide;L-trans-Epoxysuccinyl-isoleucyl-proline methyl ester propylamide;CA-074 methyl ester;(L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester;CA-074(OME)
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberC5857
  • Product descriptionCA-074 methyl ester ≥99% (TLC)
  • Packaging5MG
  • Price₹41221.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C5857 CA-074 methyl ester ≥99% (TLC) 5MG ₹41221.6 2022-06-14 Buy

Properties

Melting point :153-155°C
Boiling point :666.3±55.0 °C(Predicted)
Density :1.212±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO
pka :13.38±0.40(Predicted)
form :Solid
color :White to Off-White
InChIKey :XGWSRLSPWIEMLQ-YTFOTSKYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CA-074 methyl ester is a cell-permeable inhibitor of cathepsin B and L in vivo and in whole cells. The methyl ester is hydrolyzed by intracellular esterases releasing the active inhibitor, CA-074. This compound has primarily been used to study the role of cathepsin B in neurodegeneration, cancer cell metastasis, necrosis, and rheumatoid arthritis.

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