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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Lipid regulating drugs >Clofibrate

Clofibrate

Clofibrate Structure
  • ₹4800 - ₹45973.78
  • Product name: Clofibrate
  • CAS: 637-07-0
  • MF: C12H15ClO3
  • MW: 242.7
  • EINECS:211-277-4
  • MDL Number:MFCD00000615
  • Synonyms:Androtor;2-(4-Chlorophenoxy)isobutyric Acid Ethyl Ester Ethyl 2-(4-Chlorophenoxy)isobutyrate;2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate;2-(P-chlorophenoxy)-2-methylpropionic*acid ethyl;Phenoxyisobutyricacidethylester;Fibrate;Clofibrate 0.1;Anti-PPFIA1 (N-terminal) antibody produced in rabbit
7 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 250MG
  • 1G
  • 5G
  • 10G
  • 25G
  • 500G
  • ManufacturerTCI Chemicals (India)
  • Product numberC0941
  • Product descriptionClofibrate min. 98.0 %
  • Packaging25G
  • Price₹4800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC0941
  • Product descriptionClofibrate min. 98.0 %
  • Packaging500G
  • Price₹32700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC6643
  • Product descriptionClofibrate liquid
  • Packaging250MG
  • Price₹6538.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number41326
  • Product descriptionClofibrate analytical standard
  • Packaging100MG
  • Price₹6852.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC6643
  • Product descriptionClofibrate liquid
  • Packaging1G
  • Price₹7014.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC6643
  • Product descriptionClofibrate liquid
  • Packaging5G
  • Price₹25536.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC6643
  • Product descriptionClofibrate liquid
  • Packaging10G
  • Price₹45973.78
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C0941 Clofibrate min. 98.0 % 25G ₹4800 2022-05-26 Buy
TCI Chemicals (India) C0941 Clofibrate min. 98.0 % 500G ₹32700 2022-05-26 Buy
Sigma-Aldrich(India) C6643 Clofibrate liquid 250MG ₹6538.3 2022-06-14 Buy
Sigma-Aldrich(India) 41326 Clofibrate analytical standard 100MG ₹6852.23 2022-06-14 Buy
Sigma-Aldrich(India) C6643 Clofibrate liquid 1G ₹7014.6 2022-06-14 Buy
Sigma-Aldrich(India) C6643 Clofibrate liquid 5G ₹25536.18 2022-06-14 Buy
Sigma-Aldrich(India) C6643 Clofibrate liquid 10G ₹45973.78 2022-06-14 Buy

Properties

Melting point :<25 °C
Boiling point :154 °C
Density :1.14 g/mL at 25 °C(lit.)
refractive index :n20/D 1.503
Flash point :113 °C
storage temp. :2-8°C
solubility :Soluble to 100 mM in DMSO.
form :liquid
color :clear, colorless
Water Solubility :97.08mg/L(room temperature)
Merck :14,2377
BRN :1913459
CAS DataBase Reference :637-07-0(CAS DataBase Reference)
IARC :3 (Vol. Sup 7, 66) 1996
NIST Chemistry Reference :Clofibrate(637-07-0)
EPA Substance Registry System :Clofibrate (637-07-0)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. Clofibrate is a PPARα agonist and a member of a class of hypolipidemic drugs that includes fenofibrate and benzafibrate, which have been used clinically to treat dyslipidemia and cardiovascular disease. In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 μM for mouse and human PPARα, respectively. It also binds to PPARγ, but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 μM.

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