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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Estrogen and progestin drugs >Diethylstilbestrol

Diethylstilbestrol

Diethylstilbestrol Structure
  • ₹5315.08 - ₹113684.15
  • Product name: Diethylstilbestrol
  • CAS: 56-53-1
  • MF: C18H20O2
  • MW: 268.35
  • EINECS:200-278-5
  • MDL Number:MFCD00002373
  • Synonyms:Stibilium;Stil;Stilbe;Stilbestrol, diethyl-;Stilbestrone;Stilboefral;Stilboestroform;Stilboestrol
7 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 400μL
  • 250MG
  • 1G
  • 5G
  • 10G
  • 25G
  • ManufacturerSigma-Aldrich(India)
  • Product number46207
  • Product descriptionDiethylstilbestrol VETRANAL?, analytical standard
  • Packaging250MG
  • Price₹5315.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD4628
  • Product descriptionDiethylstilbestrol ≥99% (HPLC)
  • Packaging1G
  • Price₹10716.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD4628
  • Product descriptionDiethylstilbestrol ≥99% (HPLC)
  • Packaging5G
  • Price₹34953.93
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSAB1306249
  • Product descriptionANTI-DESMIN(C-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution
  • Packaging400μL
  • Price₹47796.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSAB1306297
  • Product descriptionANTI-DESMIN (T16) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution
  • Packaging400μL
  • Price₹47796.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD4628
  • Product descriptionDiethylstilbestrol ≥99% (HPLC)
  • Packaging10G
  • Price₹58346.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD4628
  • Product descriptionDiethylstilbestrol ≥99% (HPLC)
  • Packaging25G
  • Price₹113684.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 46207 Diethylstilbestrol VETRANAL?, analytical standard 250MG ₹5315.08 2022-06-14 Buy
Sigma-Aldrich(India) D4628 Diethylstilbestrol ≥99% (HPLC) 1G ₹10716.75 2022-06-14 Buy
Sigma-Aldrich(India) D4628 Diethylstilbestrol ≥99% (HPLC) 5G ₹34953.93 2022-06-14 Buy
Sigma-Aldrich(India) SAB1306249 ANTI-DESMIN(C-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 400μL ₹47796.6 2022-06-14 Buy
Sigma-Aldrich(India) SAB1306297 ANTI-DESMIN (T16) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 400μL ₹47796.6 2022-06-14 Buy
Sigma-Aldrich(India) D4628 Diethylstilbestrol ≥99% (HPLC) 10G ₹58346.75 2022-06-14 Buy
Sigma-Aldrich(India) D4628 Diethylstilbestrol ≥99% (HPLC) 25G ₹113684.15 2022-06-14 Buy

Properties

Melting point :170-172 °C(lit.)
Boiling point :351.51°C (rough estimate)
Density :1.1096 (rough estimate)
refractive index :1.4800 (estimate)
storage temp. :2-8°C
solubility :methanol: 0.1 g/mL, clear, faintly yellow
form :Crystalline Powder
pka :pKa 9.02(H2O t=25 I=0.025) (Uncertain)
color :White to almost white
Water Solubility :PRACTICALLY INSOLUBLE
Merck :13,3155
BRN :2056095
Stability :Isomerizes rapidly in Benzene, Chloroform, and Ether. Keep Shielded from light.
CAS DataBase Reference :56-53-1(CAS DataBase Reference)
IARC :1 (Vol. 21, Sup 7, 100A) 2012
NIST Chemistry Reference :Diethylstilbesterol(56-53-1)
EPA Substance Registry System :Diethylstilbestrol (56-53-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Diethylstilbestrol (DES) is a synthetic estrogen receptor agonist that was prescribed to pregnant women in the late 1930s. It was banned in 1971 because of possible links to increased risk of breast cancer in mothers along with congenital abnormalities and increased risk of cancer in offspring. DES is structurally related to, and is as potent as, estradiol in most assays, with a longer half-life. It has a relative binding affinity to sex hormone binding globulin (SHBG) of 0.2 compared to estradiol which has a relative binding affinity of 100. A concentration of 20 μM DES, displaces 30 ± 13% of 3H-estradiol from SHBG in serum.

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