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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >DNA damage >ATM / ATR inhibitor >ETP46464

ETP46464

ETP46464 Structure
  • ₹21209.99
  • Product name: ETP46464
  • CAS: 1345675-02-6
  • MF: C30H22N4O2
  • MW: 470.52
  • EINECS:-0
  • MDL Number:MFCD23160051
  • Synonyms:Benzeneacetonitrile, α,α-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-;alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile ETP46464;2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile;ETP46464;alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile;2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl);ETP 46464; ETP46464;ETP46464 USP/EP/BP
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product number5.00508
  • Product descriptionATR Inhibitor III, ETP-46464 - CAS 1345675-02-7 - Calbiochem
  • Packaging10MG
  • Price₹21209.99
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 5.00508 ATR Inhibitor III, ETP-46464 - CAS 1345675-02-7 - Calbiochem 10MG ₹21209.99 2022-06-14 Buy

Properties

Boiling point :709.3±60.0 °C(Predicted)
Density :1.310±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥16.13 mg/mL in DMSO
form :solid
pka :5.10±0.20(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
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Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
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Description

ETP-46464 is an inhibitor of the DNA damage response kinase Ataxia-telangiectasia mutated (ATM)- and Rad3-related (ATR) with an IC50 value of 25 nM. It also inhibits mTOR and DNA-dependent protein kinase (IC50s = 0.6 and 36 nM, respectively), and is moderately active against PI3Kα and ATM (IC50s = 170 and 545 nM, respectively). Pharmacological inhibition of ATR is reported to generate replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks. ETP-46464 has been shown to be toxic to p53-deficient cells, which is exacerbated by replicative stress-generating conditions such as the overexpression of cyclin E.

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