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FLUTICASONE FUROATE

FLUTICASONE FUROATE Structure
  • ₹8356.9 - ₹33730.7
  • Product name: FLUTICASONE FUROATE
  • CAS: 397864-44-7
  • MF: C27H29F3O6S
  • MW: 538.58
  • EINECS:222-789-2
  • MDL Number:MFCD09954122
  • Synonyms:FLUTICASONE FUROATE;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-((2- furanylcarbonyl)oxy)-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6alpha,11beta,16alpha,17alpha)-;Gw 685698x;Unii-js86977wnv;Veramyst;(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid S-(FluoroMethyl) Ester;AllerMist;AvaMys
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML3103
  • Product descriptionFluticasone furoate ≥98% (HPLC)
  • Packaging10MG
  • Price₹8356.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML3103
  • Product descriptionFluticasone furoate ≥98% (HPLC)
  • Packaging50MG
  • Price₹33730.7
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML3103 Fluticasone furoate ≥98% (HPLC) 10MG ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) SML3103 Fluticasone furoate ≥98% (HPLC) 50MG ₹33730.7 2022-06-14 Buy

Properties

Melting point :250-252°C (dec.)
Boiling point :625.2±55.0 °C(Predicted)
Density :1.39
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
pka :12.52±0.70(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Fluticasone furoate is a new corticosteroid derivative launched as a nasal spray for the treatment of seasonal and perennial allergic rhinitis in adults and in children aged ≥2 years. It is structurally closely related to the previously marketed intranasal corticosteroid fluticasone propionate (FP). Both of these steroids contain the unusual S-fluoromethyl carbothioate group, which confers high lipophilicity and hence enhanced binding and retention of the drug by the nasal tissue. Additionally, the carbothioate group rapidly undergoes first-pass metabolism by CYP3A4, thus minimizing systemic exposure of the parent drug. Fluticasone furoate is a potent ligand for the glucocorticoid receptor (GR), with a relative receptor affinity (RRA) of 2,989 with reference to dexamethasone RRA of 100.
Following intranasal administration, most of the dose is eventually swallowed and undergoes incomplete absorption and extensive firstpass metabolism in the liver and gut, resulting in negligible systemic exposure. Pharmacokinetic studies using oral solution dosing and intravenous dosing show that at least 30% of fluticasone furoate is absorbed and then rapidly cleared from plasma. The most common adverse reactions (W1% incidence) included headache, epistatix, sinus and throat pain, nasal ulceration, back pain, pyrexia, and cough. Fluticasone furoate is chemically derived starting from a readily available corticosteroid, 6a,9a-difluoro-11b,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-carboxylic acid, by first converting the carboxylic acid group to the corresponding carbothioic acid via activation with carbonyl diimidazole followed by reaction with hydrogen sulfide gas. Subsequently, selective acylation of the 17a-hydroxyl group with 2-furoyl chloride and alkylation of the 17b-carbothioic acid group with bromofluoromethane under basic conditions provides fluticasone furoate.

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