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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Endocrinology & Hormones >Estrogen / progestogen Receptor Chemical >Gestodene

Gestodene

Gestodene Structure
  • ₹7707.4 - ₹31262.6
  • Product name: Gestodene
  • CAS: 60282-87-3
  • MF: C21H26O2
  • MW: 310.43
  • EINECS:262-145-8
  • MDL Number:MFCD00867858
  • Synonyms:(8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14-decahydrocyclopenta[a]phenanthren-3-one;17-alpha-Ethynyl-13-ethyl-17-beta-hydroxy-4,15-gonadien-3-one;18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha);(17R)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one;15-ethyl-14-ethynyl-14-hydroxytetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-6,12-dien-5-one;Gestodene Methyl analogue: 17alpha-(1-Propyn-1-yl)-17a-hydroxy-18-Methyl-4,15-estradien-3-one;(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one;(8R,9S,10R,13S,14S,17S)-13-ethyl-17-ethynyl-17-hydroxy-1,7,8,10,11,12,13,17-octahydro-2H-cyclopenta[a]phenanthren-3(6H,9H,14H)-one
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0292
  • Product descriptionGestodene ≥98% (HPLC)
  • Packaging10MG
  • Price₹7707.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0292
  • Product descriptionGestodene ≥98% (HPLC)
  • Packaging50MG
  • Price₹31262.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0292 Gestodene ≥98% (HPLC) 10MG ₹7707.4 2022-06-14 Buy
Sigma-Aldrich(India) SML0292 Gestodene ≥98% (HPLC) 50MG ₹31262.6 2022-06-14 Buy

Properties

Melting point :190-192°C
Boiling point :462.7±45.0 °C(Predicted)
Density :1.15±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: >20mg/mL
pka :12.16±0.40(Predicted)
form :powder
color :white to off-white
optical activity :[α]/D -175 to -195° (DCM)
λmax :240nm(MeOH)(lit.)
Merck :14,4413
InChIKey :SIGSPDASOTUPFS-XUDSTZEESA-N
CAS DataBase Reference :60282-87-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P201 Obtain special instructions before use.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Progesterone is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Gestodene is a synthetic progesterone analog (i.e., a progestin) that is structurally related to testosterone . A USP-approved grade of gestodene is often formulated in combination with ethynyl estradiol and provided for use as an oral contraceptive. Gestodene offers a pharmacokinetic advantage over the other progestins in that it is directly active (the others are prodrugs), has high bioavailability, and is androgenically neutral. Gestodene does not bind the estrogen receptor (ER); however, two of its A-ring metabolites can bind ER and possess weak estrogenic activity.

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