GUGGULSTERONE E
|
- ₹15436.45
- Product name: GUGGULSTERONE E
- CAS: 39025-24-6
- MF: C21H28O2
- MW: 312.45
- EINECS:
- MDL Number:MFCD01310758
- Synonyms:4,17(20)-(TRANS)-PREGNADIEN-3,16-DIONE;GS, TRANS;GUGGULESTERONE E;GUGGULSTERONE;GUGGULSTERONE E;GUGGULSTERONE (E FORM);TRANS-4,17(20)-PREGNADIENE-3,16-DIONE;TRANS-GUGGULSTERONE
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberG4923
- Product description(E)-Guggulsterone ≥95% (HPLC), powder
- Packaging5MG
- Price₹15436.45
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G4923 | (E)-Guggulsterone ≥95% (HPLC), powder | 5MG | ₹15436.45 | 2022-06-14 | Buy |
Properties
Melting point :170-171.5°
alpha :D26 -30° (c = 1 in chloroform)
Boiling point :463℃
Density :1.10
Flash point :172℃
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL
form :powder
color :white to off-white
LogP :3.650 (est)
alpha :D26 -30° (c = 1 in chloroform)
Boiling point :463℃
Density :1.10
Flash point :172℃
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL
form :powder
color :white to off-white
LogP :3.650 (est)
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis. Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo. The cis stereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 15 M. By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.More related product prices
Pregnenolone Gestrinone 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Gestodene Eltanolone (Z)-GuggulsteroneRelated product price
- (Z)-Guggulsterone
₹23490.25-83688.08 - Pregnenolone
₹2446.45-56971.98 - 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL
₹4100-10400
