IRAK-1/4 INHIBITOR I
|
- ₹10310 - ₹62914.9
- Product name: IRAK-1/4 INHIBITOR I
- CAS: 509093-47-4
- MF: C20H21N5O4
- MW: 395.41
- EINECS:
- MDL Number:MFCD09752602
- Synonyms:3-Nitro-N-(1-(2-morpholin-4-ylethyl)-1H-benzimidazol-2-yl)benzamide;BenzaMide, N-[1-[2-(4-Morpholinyl)ethyl]-1H-benziMidazol-2-yl]-3-nitro-;Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor ;IIRAK-1-4 Inhibitor I;1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole;N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole;IRAK-1/4 INHIBITOR I
4 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product number407602
- Product descriptionInSolution Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for P
- Packaging5MG
- Price₹10310
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number407601
- Product descriptionInterleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for P
- Packaging5MG
- Price₹13100
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberI5409
- Product descriptionIRAK-1/4 Inhibitor I ≥98% (HPLC), solid
- Packaging5MG
- Price₹15761.2
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberI5409
- Product descriptionIRAK-1/4 Inhibitor I ≥98% (HPLC), solid
- Packaging25MG
- Price₹62914.9
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 407602 | InSolution Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for P | 5MG | ₹10310 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 407601 | Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for P | 5MG | ₹13100 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I5409 | IRAK-1/4 Inhibitor I ≥98% (HPLC), solid | 5MG | ₹15761.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I5409 | IRAK-1/4 Inhibitor I ≥98% (HPLC), solid | 25MG | ₹62914.9 | 2022-06-14 | Buy |
Properties
Density :1.40
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL
form :Yellow crystalline solid
pka :11.54±0.43(Predicted)
color :off-white to light yellow
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL
form :Yellow crystalline solid
pka :11.54±0.43(Predicted)
color :off-white to light yellow
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-κB activity, results in the development of some cancers and other diseases, making the development of IRAK inhibitors a potential therapeutic strategy. IRAK-1/4 inhibitor is a benzimidazole that disrupts the activity of IRAK-1 and -4 with IC50 values of 0.3 and 0.2 μM, respectively. It demonstrates IC50 values >10 μM in a panel of 27 other kinases tested. This compound has been used to inhibit a pro-inflammatory response in microglia isolated from clinically diagnosed Alzheimer’s disease patients.More related product prices
DEMETON SRelated product price
- IRAK-1/4 INHIBITOR I
₹10310-62914.9
