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LINOLEOYLETHANOLAMIDE

LINOLEOYLETHANOLAMIDE Structure
  • ₹30526.5
  • Product name: LINOLEOYLETHANOLAMIDE
  • CAS: 68171-52-8
  • MF: C20H37NO2
  • MW: 323.51
  • EINECS:269-029-6
  • MDL Number:MFCD00674434
  • Synonyms:N-(2-HYDROXYETHYL)-9Z, 12Z-OCTADECADIENAMIDE;ODNHETOH;LEA;n-(2-hydroxyethyl)-,(z,z)-12-octadecadienamide ;(9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dien-1-amide ;9,12-Octadecadienamide, N-(2-hydroxyethyl)-, (9Z,12Z)-;Linoleic ethanolamine;(9Z,12Z)-N-(2-Hydroxyethyl)-9,12-octadecadienamide
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberL1164
  • Product descriptionLinoleyl ethanolamide ≥98%, ethanol solution
  • Packaging10MG
  • Price₹30526.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) L1164 Linoleyl ethanolamide ≥98%, ethanol solution 10MG ₹30526.5 2022-06-14 Buy

Properties

Melting point :38-40 °C
Boiling point :499.1±38.0 °C(Predicted)
Density :0.926±0.06 g/cm3(Predicted)
Flash point :14 °C
storage temp. :-20°C
solubility :DMF:25.0(Max Conc. mg/mL);77.27(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);77.27(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);154.55(Max Conc. mM) form :ethanol solution
pka :14.49±0.10(Predicted)
color :Light yellow to light brown
Stability :Light Sensitive, Temperature Sensitive
LogP :6.003 (est)
EPA Substance Registry System :9,12-Octadecadienamide, N-(2-hydroxyethyl)-, (9Z,12Z)- (68171-52-8)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonyl ethanolamide (AEA). It has weak affinity for the cannabinoid 1 (CB1) and CB2 receptors, exhibiting Ki values of 10 μM and 25 μM, respectively. However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg). In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 μM in a CB-receptor-independent manner. However, cellular toxicity is readily apparent at concentrations of 10-20 μM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 μM, but also is hydrolyzed effectively by the enzyme.

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