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ChemicalBook > Product Catalogue >API >Antiparasitic drugs >Anthelmintics >Mebendazole

Mebendazole

Mebendazole Structure
  • ₹2800 - ₹22764.98
  • Product name: Mebendazole
  • CAS: 31431-39-7
  • MF: C16H13N3O3
  • MW: 295.29
  • EINECS:250-635-4
  • MDL Number:MFCD00057872
  • Synonyms:(5-benzoyl-1h-benzimidazol-2-yl)-carbamicacidmethylester ;(5-benzoyl-1h-benzimidazol-2-yl)-carbamicacimethylester ;5-benzoyl-2-benzimidazolecarbamicacimethylester ;bantenol ;besantin ;lomper ;mbdz ;mebenvet
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 250MG
  • 300MG
  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberM2273
  • Product descriptionMebendazole
  • Packaging5G
  • Price₹2800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberM2273
  • Product descriptionMebendazole
  • Packaging25G
  • Price₹6800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM2523
  • Product descriptionMebendazole analytical standard, ≥98% (HPLC)
  • Packaging25G
  • Price₹9374.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number46404
  • Product descriptionMebendazole VETRANAL?, analytical standard
  • Packaging250MG
  • Price₹11669.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2448
  • Product descriptionMebendazole Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging300MG
  • Price₹22764.98
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) M2273 Mebendazole 5G ₹2800 2022-05-26 Buy
TCI Chemicals (India) M2273 Mebendazole 25G ₹6800 2022-05-26 Buy
Sigma-Aldrich(India) M2523 Mebendazole analytical standard, ≥98% (HPLC) 25G ₹9374.45 2022-06-14 Buy
Sigma-Aldrich(India) 46404 Mebendazole VETRANAL?, analytical standard 250MG ₹11669.35 2022-06-14 Buy
Sigma-Aldrich(India) PHR2448 Mebendazole Pharmaceutical Secondary Standard; Certified Reference Material 300MG ₹22764.98 2022-06-14 Buy

Properties

Melting point :288.5°C
Boiling point :436.98°C (rough estimate)
Density :1.1952 (rough estimate)
refractive index :1.6500 (estimate)
storage temp. :Sealed in dry,2-8°C
solubility :Practically insoluble in water, in alcohol and in methylene chloride.
form :Solid
pka :pKa 3.43/9.93(H2O,t =25,I=0.025) (Uncertain)
color :White to Pale Beige
Water Solubility :35.4mg/L(25 ºC)
Merck :14,5768
BRN :759809
BCS Class :2,4
CAS DataBase Reference :31431-39-7(CAS DataBase Reference)
EPA Substance Registry System :Mebendazole (31431-39-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:

Description

Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 μM for Giardia in vitro). As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration. Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation. Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.

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Suppliers and manufacturers

Jigs Chemical ltd Cipla Ltd Ions Pharma Varahi International Supharma Chem Humble Healthcare Limited Manasvi Life Sciences Syglak Laboratories Pvt Ltd Solara Active Pharma Sciences Ltd Ralington Pharma