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ChemicalBook > Product Catalogue >Biochemical Engineering >Polypeptide >MELITTIN

MELITTIN

MELITTIN Structure
  • ₹10670
  • Product name: MELITTIN
  • CAS: 37231-28-0
  • MF: C131H229N39O31
  • MW: 2846.46
  • EINECS:253-417-7
  • MDL Number:MFCD00076868
  • Synonyms:melittinfrombeevenomsequencing*grade ;melittinhoneybeevenom ;melittin-t ;MELLITIN;MELITTIN;MELITTIN (NATURAL);GIGAVLKVLTTGLPALISWIKRKRQQ-NH2;H-GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2
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Brand

  • Sigma-Aldrich(India)

Package

  • 250μG
  • ManufacturerSigma-Aldrich(India)
  • Product number444605
  • Product descriptionMelittin - CAS 37231-28-0 - Calbiochem A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner.
  • Packaging250μG
  • Price₹10670
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 444605 Melittin - CAS 37231-28-0 - Calbiochem A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner. 250μG ₹10670 2022-06-14 Buy

Properties

Melting point :>121°C (dec.)
Flash point :112 °C
storage temp. :2-8°C
solubility :Water (Slightly)
form :White to off-white powder.
color :White to Light Yellow
Merck :13,5846
Stability :Stable. Incompatible with strong oxidizing agents.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P322 Specific measures (see …on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee, A. mellifera. Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side. This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2 (PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2 enzymes in the venom. Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.

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