MITHRAMYCIN A
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- ₹20578.33 - ₹84738.1
- Product name: MITHRAMYCIN A
- CAS: 18378-89-7
- MF: C52H76O24
- MW: 1085.15
- EINECS:634-048-4
- MDL Number:MFCD00135618
- Synonyms:AUREOLIC ACID;METHRAMYCIN A;MITHRAMYCIN A, FOR FLUORESCENCE;MITHRAMYCIN A FROM STREPTOMYCES*PLICATUS APPROX. 96;MITHRAMYCIN COMPLEX FROM STREPTOMYCES*PL ICATUS;MITHRAMYCIN FROM STREPTOMYCES PLICATUS;MITHRACIN;MITHRAMYCIN A
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberM6891
- Product descriptionMithramycin A from Streptomyces plicatus ≥90% (HPLC)
- Packaging1MG
- Price₹20578.33
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberM6891
- Product descriptionMithramycin A from Streptomyces plicatus ≥90% (HPLC)
- Packaging5MG
- Price₹84738.1
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M6891 | Mithramycin A from Streptomyces plicatus ≥90% (HPLC) | 1MG | ₹20578.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M6891 | Mithramycin A from Streptomyces plicatus ≥90% (HPLC) | 5MG | ₹84738.1 | 2022-06-14 | Buy |
Properties
Melting point :180-183 °C
alpha :D20 -51° (c = 0.4 in ethanol)
Boiling point :761.72°C (rough estimate)
Density :1.1576 (rough estimate)
refractive index :1.6500 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml)
form :Powder
pka :4.54±0.60(Predicted)
color :Red to brown
Merck :13,7619
BRN :5236667
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
EPA Substance Registry System :Plicamycin (18378-89-7)
alpha :D20 -51° (c = 0.4 in ethanol)
Boiling point :761.72°C (rough estimate)
Density :1.1576 (rough estimate)
refractive index :1.6500 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml)
form :Powder
pka :4.54±0.60(Predicted)
color :Red to brown
Merck :13,7619
BRN :5236667
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
EPA Substance Registry System :Plicamycin (18378-89-7)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic originally isolated from S. grieseus that has long been used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression. Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models.Related product price
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