MONOCROTALINE
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- ₹29692.98 - ₹51180.6
- Product name: MONOCROTALINE
- CAS: 315-22-0
- MF: C16H23NO6
- MW: 325.36
- EINECS:628-506-2
- MDL Number:MFCD00084656
- Synonyms:(13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dio ;(13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione;(2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihy ;(2,3,4-gh)pyrrolizine-2,6(3H)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino-;12-beta,13-beta-dihydroxy-12-alpha,13-alpha,14-alpha-trimethylcrotal-1-enine ;12beta,13beta-Dihydroxy-12alpha,13alpha,14alpha-trimethylcrotal-1-enine;14,19-dihydro-12,13-dihydroxy(13-alpha,14-alpha)-20-norcrotalanan-11,15-dione ;14,19-Dihydro-12,13-dihydroxy(13alpha,14alpha)-20-norcrotalanan-11,15-dione
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 500MG
- 1G
- ManufacturerSigma-Aldrich(India)
- Product numberC2401
- Product descriptionCrotaline
- Packaging1G
- Price₹51180.6
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberC2401
- Product descriptionCrotaline
- Packaging500MG
- Price₹29692.98
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C2401 | Crotaline | 1G | ₹51180.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C2401 | Crotaline | 500MG | ₹29692.98 | 2022-06-14 | Buy |
Properties
Melting point :204 °C (dec.) (lit.)
alpha :-54.8o (C=5 IN CHLOROFORM)
Boiling point :463.55°C (rough estimate)
Density :1.1512 (rough estimate)
refractive index :1.5500 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)
form :Solid
pka :12.21±0.60(Predicted)
color :White
Water Solubility :11.86g/L(temperature not stated)
Merck :13,6274
BRN :48732
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :QVCMHGGNRFRMAD-XFGHUUIASA-N
LogP :-0.370 (est)
IARC :2B (Vol. 10, Sup 7) 1987
EPA Substance Registry System :Monocrotaline (315-22-0)
alpha :-54.8o (C=5 IN CHLOROFORM)
Boiling point :463.55°C (rough estimate)
Density :1.1512 (rough estimate)
refractive index :1.5500 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)
form :Solid
pka :12.21±0.60(Predicted)
color :White
Water Solubility :11.86g/L(temperature not stated)
Merck :13,6274
BRN :48732
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :QVCMHGGNRFRMAD-XFGHUUIASA-N
LogP :-0.370 (est)
IARC :2B (Vol. 10, Sup 7) 1987
EPA Substance Registry System :Monocrotaline (315-22-0)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Monocrotaline (MCT) is a toxic 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant. It poisons livestock and humans through the ingestion of contaminated grains and other foods. Pyrrolizidine alkaloid is activated by cytochrome P450 to the reactive pyrrole metabolite dehydromonocrotaline (MCTP) in the liver. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature.Monocrotaline is produced for research use. It is used in rat model to investigate human pulmonary hypertension as it offers technical simplicity, reproducibility, and low cost compared with other models of pulmonary hypertension.
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