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NO-1886

NO-1886 Structure
  • ₹20719.05 - ₹82746.3
  • Product name: NO-1886
  • CAS: 133208-93-2
  • MF: C19H20BrN2O4P
  • MW: 451.25
  • EINECS:
  • MDL Number:MFCD00897807
  • Synonyms:OPF 009;Lipoprotein Lipase Activator;NO-1886;Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate;4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide;ibrolipim;Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate, Ibrolipim, OPF 009;Ibrolipim NO-1886
Price2 Properties Safety Information Description
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberN1540
  • Product descriptionNO-1886
  • Packaging5MG
  • Price₹20719.05
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN1540
  • Product descriptionNO-1886
  • Packaging25MG
  • Price₹82746.3
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) N1540 NO-1886 5MG ₹20719.05 2022-06-14 Buy
Sigma-Aldrich(India) N1540 NO-1886 25MG ₹82746.3 2022-06-14 Buy

Properties

Melting point :160.5-162.1 °C
Boiling point :512.5±50.0 °C(Predicted)
Density :1.44±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
pka :11.51±0.70(Predicted)
color :off-white to pale yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Lipoprotein lipase (LPL) mediates the hydrolysis of triglycerides in circulating very low density lipoproteins and chylomicrons. NO-1886 is an LPL activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle. This coincides with an elevation in post-heparin plasma LPL activity and LPL mass in rats. NO-1886 decreases plasma triglyceride concentration and increases plasma high-density lipoprotein cholesterol, resulting in inhibited development of atherosclerotic lesions in coronary arteries and aortas of rats and rabbits.

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