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NPPB

NPPB Structure
  • ₹10670 - ₹32910
  • Product name: NPPB
  • CAS: 107254-86-4
  • MF: C16H16N2O4
  • MW: 300.31
  • EINECS:
  • MDL Number:MFCD00153851
  • Synonyms:5-NITRO-2-(3'-PHENYLPROPYL-AMINO)BENZOIC ACID;5-NITRO-2-(3-PHENYLPROPYLAMINO)BENZOIC ACID;NPPB;5-NITRO-2-(3-PHENYLPROPYLAMINO)BENZOIC A CID POTENT CHLORIDE CHANN;5-NITRO-2-(3-PHENYLPROPYLAMINO)-BENZOIC ACID 98%;3-Nitro-6-[(3-phenylpropyl)amino]benzoic acid;Compound 144;C13705
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 25MG
  • 100MG
  • ManufacturerSigma-Aldrich(India)
  • Product number484100
  • Product description5-Nitro-2-(3-phenylpropylamino)benzoic Acid - CAS 107254-86-4 - Calbiochem Potent Cl? channel blocker (IC?? = 100 nM-100 μM), depending on channel subtype and assay method.
  • Packaging10MG
  • Price₹10670
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN4779
  • Product description5-Nitro-2-(3-phenylpropylamino)benzoic acid ≥98%
  • Packaging25MG
  • Price₹11800
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN4779
  • Product description5-Nitro-2-(3-phenylpropylamino)benzoic acid ≥98%
  • Packaging100MG
  • Price₹32910
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 484100 5-Nitro-2-(3-phenylpropylamino)benzoic Acid - CAS 107254-86-4 - Calbiochem Potent Cl? channel blocker (IC?? = 100 nM-100 μM), depending on channel subtype and assay method. 10MG ₹10670 2022-06-14 Buy
Sigma-Aldrich(India) N4779 5-Nitro-2-(3-phenylpropylamino)benzoic acid ≥98% 25MG ₹11800 2022-06-14 Buy
Sigma-Aldrich(India) N4779 5-Nitro-2-(3-phenylpropylamino)benzoic acid ≥98% 100MG ₹32910 2022-06-14 Buy

Properties

Melting point :178-180℃
Boiling point :523.5±50.0 °C(Predicted)
Density :1.323±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :ethanol: 3 mg/mL
pka :2.27±0.22(Predicted)
form :Yellow solid
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

NPPB is a chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist. It has been shown to activate the GPR35-Gαi/o and GPR35-Gα16 pathways in HEK293 cells, inducing intracellular calcium mobilization. NPPB has protonophoric activity and has been used to uncouple mitochondrial ATP synthesis in phagocytes.

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