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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >PUROMYCIN AMINONUCLEOSIDE

PUROMYCIN AMINONUCLEOSIDE

PUROMYCIN AMINONUCLEOSIDE Structure
  • ₹15999.35 - ₹218946.45
  • Product name: PUROMYCIN AMINONUCLEOSIDE
  • CAS: 58-60-6
  • MF: C12H18N6O3
  • MW: 294.31
  • EINECS:200-388-3
  • MDL Number:MFCD00063462
  • Synonyms:3’-amino-3’-deoxy-n,n-dimethyl-adenosin ;6-(dimethylamino)-9-(3-amino-3-deoxy-beta-d-ribofuranosyl)purine ;9-(3-amino-3-deoxy-beta-d-ribofuranosyl)-6-(dimethylamino)-9h-purine ;aminonucleoside ;aminonucleosidepuromycin ;stylomycinaminonucleoside ;PUROMYCIN AMINONUCLEOSIDE;6-DIMETHYLAMIN-9-[3'-AMINO-3'DEOXYRIBOSYL]-PURINE
4 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • 500MG
  • 1G
  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberSBR00017
  • Product descriptionPuromycin aminonucleoside Ready Made Solution 10?mg/mL in water
  • Packaging1ML
  • Price₹15999.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP7130
  • Product descriptionPuromycin aminonucleoside
  • Packaging100MG
  • Price₹30602.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP7130
  • Product descriptionPuromycin aminonucleoside
  • Packaging500MG
  • Price₹116563.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP7130
  • Product descriptionPuromycin aminonucleoside
  • Packaging1G
  • Price₹218946.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SBR00017 Puromycin aminonucleoside Ready Made Solution 10?mg/mL in water 1ML ₹15999.35 2022-06-14 Buy
Sigma-Aldrich(India) P7130 Puromycin aminonucleoside 100MG ₹30602.28 2022-06-14 Buy
Sigma-Aldrich(India) P7130 Puromycin aminonucleoside 500MG ₹116563.6 2022-06-14 Buy
Sigma-Aldrich(India) P7130 Puromycin aminonucleoside 1G ₹218946.45 2022-06-14 Buy

Properties

Melting point :235℃ (Decomposition)
Boiling point :436.08°C (rough estimate)
Density :1.2131 (rough estimate)
refractive index :1.7000 (estimate)
Flash point :>110°(230°F)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :H2O: 50 mg/mL, clear, slightly yellow
form :liquid
pka :13.26±0.70(Predicted)
color :White
Water Solubility :Soluble in water at 50mg/ml. May require heating
BRN :93902
Stability :Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
InChIKey :RYSMHWILUNYBFW-GRIPGOBMSA-N
EPA Substance Registry System :Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P314 Get medical advice/attention if you feel unwell.

Description

Puromycin is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains. Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria. When administered to rats at 0.5-5 μM, PANS affects glomerular epithelial cell adhesion, reducing α3β1 integrin expression. PANS also has been shown to decrease nephrin and podocin expression.

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