TH287
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- ₹14130.3
- Product name: TH287
- CAS: 1609960-30-6
- MF: C11H10Cl2N4
- MW: 269.13
- EINECS:-0
- MDL Number:MFCD29035111
- Synonyms:TH287 hydrochloride;TH287;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine;TH287;TH-287;CS-1671;TH287, >98%
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1069
- Product descriptionTH287 hydrochloride ≥98% (HPLC)
- Packaging5MG
- Price₹14130.3
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1069 | TH287 hydrochloride ≥98% (HPLC) | 5MG | ₹14130.3 | 2022-06-14 | Buy |
Properties
Boiling point :512.2±60.0 °C(Predicted)
Density :1.440±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :5.91±0.10(Predicted)
form :powder
color :white to beige
Density :1.440±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :5.91±0.10(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).More related product prices
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