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TIMTEC-BB SBB005393

TIMTEC-BB SBB005393 Structure
  • ₹5401.68 - ₹20978.85
  • Product name: TIMTEC-BB SBB005393
  • CAS: 72214-67-6
  • MF: C8H9Cl3N2S
  • MW: 271.6
  • EINECS:
  • MDL Number:MFCD00035047
  • Synonyms:TIMTEC-BB SBB005393;(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride;2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride;Rb/Raf-1 disruptor 251 hydrochloride;S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride;(2,4-dichlorophenyl)methylsulfanylformamidine hydrochloride;(2,4-dichlorophenyl)methylsulfanylmethanimidamide hydrochloride;[(2,4-dichlorobenzyl)thio]formamidine hydrochloride
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberR7532
  • Product descriptionRRD-251 hydrochloride ≥98% (HPLC)
  • Packaging5MG
  • Price₹5401.68
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR7532
  • Product descriptionRRD-251 hydrochloride ≥98% (HPLC)
  • Packaging25MG
  • Price₹20978.85
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) R7532 RRD-251 hydrochloride ≥98% (HPLC) 5MG ₹5401.68 2022-06-14 Buy
Sigma-Aldrich(India) R7532 RRD-251 hydrochloride ≥98% (HPLC) 25MG ₹20978.85 2022-06-14 Buy

Properties

Melting point :222-227 °C
storage temp. :room temp
solubility :DMSO: >10mg/mL
form :White solid
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

Description

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.