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ChemicalBook >> CAS DataBase List >> IMD-0354

IMD-0354

IMD-0354 price.
  • $33 - $1528
  • Product name: IMD-0354
  • CAS: 978-62-1
  • MF: C15H8ClF6NO2
  • MW: 383.67
  • EINECS:
  • MDL Number:MFCD00218820
  • Synonyms:Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-;N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354;IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem;IKK-2 INHIBITOR V; IMD 0354;IMD0354;;IMD-0354, 99%, a synthetic selective NF-kB inhibitor;IMD 0354;IMD-0354;IMD-0354 USP/EP/BP;IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354
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Brand
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2473AH
  • Product descriptionIMD0354
  • Packaging1g
  • Price$1269
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ65132
  • Product descriptionIKK-2 Inhibitor V
  • Packaging10mg
  • Price$156
  • Updated2023-06-20
  • Buy
  • ManufacturerAmbeed
  • Product numberA232738
  • Product descriptionIMD-0354 98+%
  • Packaging1mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA232738
  • Product descriptionIMD-0354 98+%
  • Packaging5mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA232738
  • Product descriptionIMD-0354 98+%
  • Packaging10mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA232738
  • Product descriptionIMD-0354 98+%
  • Packaging50mg
  • Price$202
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA232738
  • Product descriptionIMD-0354 98+%
  • Packaging100mg
  • Price$392
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA232738
  • Product descriptionIMD-0354 98+%
  • Packaging250mg
  • Price$593
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA232738
  • Product descriptionIMD-0354 98+%
  • Packaging1g
  • Price$1528
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000857
  • Product descriptionIMD-0354 95.00%
  • Packaging1MG
  • Price$140.7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000857
  • Product descriptionIMD-0354 95.00%
  • Packaging10MG
  • Price$697.34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000857
  • Product descriptionIMD-0354 95.00%
  • Packaging50MG
  • Price$1170.31
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1587
  • Product descriptionIMD0354
  • Packaging10mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS487423
  • Product descriptionIMD-0354 ≥98%
  • Packaging1mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS487423
  • Product descriptionIMD-0354 ≥98%
  • Packaging5mg
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS487423
  • Product descriptionIMD-0354 ≥98%
  • Packaging10mg
  • Price$86
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2473AH IMD0354 1g $1269 2021-12-16 Buy
Alfa Aesar J65132 IKK-2 Inhibitor V 10mg $156 2023-06-20 Buy
Ambeed A232738 IMD-0354 98+% 1mg $33 2021-12-16 Buy
Ambeed A232738 IMD-0354 98+% 5mg $59 2021-12-16 Buy
Ambeed A232738 IMD-0354 98+% 10mg $87 2021-12-16 Buy
Ambeed A232738 IMD-0354 98+% 50mg $202 2021-12-16 Buy
Ambeed A232738 IMD-0354 98+% 100mg $392 2021-12-16 Buy
Ambeed A232738 IMD-0354 98+% 250mg $593 2021-12-16 Buy
Ambeed A232738 IMD-0354 98+% 1g $1528 2021-12-16 Buy
American Custom Chemicals Corporation INB0000857 IMD-0354 95.00% 1MG $140.7 2021-12-16 Buy
American Custom Chemicals Corporation INB0000857 IMD-0354 95.00% 10MG $697.34 2021-12-16 Buy
American Custom Chemicals Corporation INB0000857 IMD-0354 95.00% 50MG $1170.31 2021-12-16 Buy
ApexBio Technology B1587 IMD0354 10mg $77 2021-12-16 Buy
Arctom AS487423 IMD-0354 ≥98% 1mg $33 2021-12-16 Buy
Arctom AS487423 IMD-0354 ≥98% 5mg $58 2021-12-16 Buy
Arctom AS487423 IMD-0354 ≥98% 10mg $86 2021-12-16 Buy

Properties

Boiling point :323.1±42.0 °C(Predicted)
Density :1.561
storage temp. :-20°C
solubility :DMSO (5 mg/ml) or Ethanol (1 mg/ml).
form :White solid
pka :7.61±0.43(Predicted)
color :White to off-white
Sensitive :Light Sensitive
CAS DataBase Reference :978-62-1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.

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